AmiGO 2: Term Details for "helicase activity" (GO:0004386)

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Term Information

Accession: GO:0004386
Name: helicase activity
Ontology: molecular_function
Synonyms: ATP-dependent helicase activity
Alternate IDs: GO:0008026
Definition: Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. Source: GOC:jl
Comment: Note that most helicases catalyze processive duplex unwinding.
History: See term history for GO:0004386 at QuickGO
Chem. react.: None
Subset: goslim_chembl; goslim_yeast; goslim_candida; goslim_pir
Related: Link to all genes and gene products annotated to helicase activity (excluding "regulates").; Link to all direct and indirect annotations to helicase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for helicase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0140657 ATP-dependent activity
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0004386 helicase activity
GO:0003678 DNA helicase activity
GO:0033677 DNA/RNA helicase activity
GO:0051097 negative regulation of helicase activity
GO:0051096 positive regulation of helicase activity
GO:0051095 regulation of helicase activity
GO:0003724 RNA helicase activity

Parents of helicase activity (GO:0004386)

subject	relation	object
helicase activity	is_a	ATP-dependent activity (GO:0140657)
helicase activity	is_a	catalytic activity, acting on a nucleic acid (GO:0140640)

Children of helicase activity (GO:0004386)

subject	relation	object
negative regulation of helicase activity (GO:0051097)	RO:0002212	helicase activity
DNA helicase activity (GO:0003678)	is_a	helicase activity
RNA helicase activity (GO:0003724)	is_a	helicase activity
positive regulation of helicase activity (GO:0051096)	RO:0002213	helicase activity
regulation of helicase activity (GO:0051095)	RO:0002211	helicase activity
DNA/RNA helicase activity (GO:0033677)	is_a	helicase activity

Reactome: R-HSA-5690996; R-HSA-169461; R-HSA-5686410; R-HSA-169468