AmiGO 2: Term Details for "histone deacetylase activity" (GO:0004407)

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Term Information

Accession: GO:0004407
Name: histone deacetylase activity
Ontology: molecular_function
Synonyms: None
Alternate IDs: None
Definition: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes. Source: RHEA:58196, PMID:9893272
Comment: None
History: See term history for GO:0004407 at QuickGO
Chem. react.: has participant L-lysinium residue; has participant acetate; has participant N(6)-acetyl-L-lysine residue; has participant water
Subset: None
Related: Link to all genes and gene products annotated to histone deacetylase activity (excluding "regulates").; Link to all direct and indirect annotations to histone deacetylase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for histone deacetylase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0071840 cellular component organization or biogenesis
GO:0016043 cellular component organization
GO:0043933 protein-containing complex organization
GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0071824 protein-DNA complex organization
GO:0006325 chromatin organization
GO:0016787 hydrolase activity
GO:0140096 catalytic activity, acting on a protein
GO:0006338 chromatin remodeling
GO:0019213 deacetylase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0140993 histone modifying activity
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0033558 protein lysine deacetylase activity
GO:0004407 histone deacetylase activity
GO:0000118 histone deacetylase complex
GO:0141050 histone H3K deacetylase activity
GO:0141051 histone H4K deacetylase activity
GO:0017136 NAD-dependent histone deacetylase activity
GO:0045129 NAD-independent histone deacetylase activity

Parents of histone deacetylase activity (GO:0004407)

subject	relation	object
histone deacetylase activity	is_a	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811)
histone deacetylase activity	is_a	histone modifying activity (GO:0140993)
histone deacetylase activity	RO:0000057	L-lysinium residue (CHEBI:29969)
histone deacetylase activity	RO:0000057	acetate (CHEBI:30089)
histone deacetylase activity	is_a	protein lysine deacetylase activity (GO:0033558)
histone deacetylase activity	RO:0000057	N(6)-acetyl-L-lysine residue (CHEBI:61930)
histone deacetylase activity	RO:0000057	water (CHEBI:15377)

Children of histone deacetylase activity (GO:0004407)

subject	relation	object
histone H4K deacetylase activity (GO:0141051)	is_a	histone deacetylase activity
histone deacetylase complex (GO:0000118)	RO:0002215	histone deacetylase activity
NAD-independent histone deacetylase activity (GO:0045129)	is_a	histone deacetylase activity
histone deacetylase inhibitor activity (GO:0046811)	RO:0002630	histone deacetylase activity
histone deacetylase regulator activity (GO:0035033)	RO:0002578	histone deacetylase activity
histone H3K deacetylase activity (GO:0141050)	is_a	histone deacetylase activity
NAD-dependent histone deacetylase activity (GO:0017136)	is_a	histone deacetylase activity

EC: 3.5.1.98
MetaCyc: 3.5.1.98-RXN
Reactome: R-HSA-2545203; R-HSA-3769447; R-HSA-433672; R-HSA-3777129; R-HSA-427514; R-HSA-3782655; R-HSA-6805650; R-HSA-3782637; R-HSA-2545253
RHEA: 58196