AmiGO 2: Term Details for "homocitrate synthase activity" (GO:0004410)

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Term Information

Accession: GO:0004410
Name: homocitrate synthase activity
Ontology: molecular_function
Synonyms: 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity, 2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating), acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming), acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity, homocitrate synthetase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H2O = CoA + H+ + homocitrate. Source: RHEA:12929
Comment: Note that this function was formerly EC:4.1.3.21.
History: See term history for GO:0004410 at QuickGO
Chem. react.: has participant 2-oxoglutarate(2-); has participant coenzyme A(4-); has participant hydron; has participant acetyl-CoA(4-); has participant (2R)-homocitrate(3-); has participant water
Subset: None
Related: Link to all genes and gene products annotated to homocitrate synthase activity (excluding "regulates").; Link to all direct and indirect annotations to homocitrate synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for homocitrate synthase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016746 acyltransferase activity
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer
GO:0004410 homocitrate synthase activity

Parents of homocitrate synthase activity (GO:0004410)

subject	relation	object
homocitrate synthase activity	RO:0000057	2-oxoglutarate(2-) (CHEBI:16810)
homocitrate synthase activity	RO:0000057	coenzyme A(4-) (CHEBI:57287)
homocitrate synthase activity	is_a	acyltransferase activity, acyl groups converted into alkyl on transfer (GO:0046912)
homocitrate synthase activity	RO:0000057	hydron (CHEBI:15378)
homocitrate synthase activity	RO:0000057	acetyl-CoA(4-) (CHEBI:57288)
homocitrate synthase activity	RO:0000057	(2R)-homocitrate(3-) (CHEBI:58884)
homocitrate synthase activity	RO:0000057	water (CHEBI:15377)

This term has no children.

EC: 2.3.3.14
KEGG_REACTION: R00271
MetaCyc: HOMOCITRATE-SYNTHASE-RXN
RHEA: 12929