AmiGO 2: Term Details for "hydroxymethylbilane synthase activity" (GO:0004418)

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Term Information

Accession: GO:0004418
Name: hydroxymethylbilane synthase activity
Ontology: molecular_function
Synonyms: (4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity, (4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing), HMB-synthase activity, porphobilinogen ammonia-lyase (polymerizing), porphobilinogen deaminase activity, porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing), pre-uroporphyrinogen synthase activity, uroporphyrinogen synthase activity, uroporphyrinogen synthetase activity, uroporphyrinogen I synthase activity, uroporphyrinogen I synthetase activity
Alternate IDs: None
Definition: Catalysis of the reaction: H2O + 4 porphobilinogen = hydroxymethylbilane + 4 NH4. Source: RHEA:13185, EC:2.5.1.61
Comment: Note that this function was formerly EC:4.3.1.8.
History: See term history for GO:0004418 at QuickGO
Chem. react.: has participant water; has participant preuroporphyrinogen(8-); has participant ammonium; has participant porphobilinogen(1-)
Subset: None
Related: Link to all genes and gene products annotated to hydroxymethylbilane synthase activity (excluding "regulates").; Link to all direct and indirect annotations to hydroxymethylbilane synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for hydroxymethylbilane synthase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016740 transferase activity
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0004418 hydroxymethylbilane synthase activity

Parents of hydroxymethylbilane synthase activity (GO:0004418)

subject	relation	object
hydroxymethylbilane synthase activity	RO:0000057	water (CHEBI:15377)
hydroxymethylbilane synthase activity	is_a	transferase activity, transferring alkyl or aryl (other than methyl) groups (GO:0016765)
hydroxymethylbilane synthase activity	RO:0000057	preuroporphyrinogen(8-) (CHEBI:57845)
hydroxymethylbilane synthase activity	RO:0000057	ammonium (CHEBI:28938)
hydroxymethylbilane synthase activity	RO:0000057	porphobilinogen(1-) (CHEBI:58126)

This term has no children.

EC: 2.5.1.61
KEGG_REACTION: R00084
MetaCyc: OHMETHYLBILANESYN-RXN
Reactome: R-HSA-189406
RHEA: 13185