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hydroxymethylglutaryl-CoA lyase activity

Term Information

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Accession
GO:0004419
Name
hydroxymethylglutaryl-CoA lyase activity
Ontology
molecular_function
Synonyms
(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming), (S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity, 3-hydroxy-3-methylglutarate-CoA lyase activity, 3-hydroxy-3-methylglutaryl CoA cleaving enzyme, 3-hydroxy-3-methylglutaryl coenzyme A lyase activity, 3-hydroxy-3-methylglutaryl-CoA lyase activity, HMG-CoA lyase activity, hydroxymethylglutaryl coenzyme A lyase activity, hydroxymethylglutaryl coenzyme A-cleaving enzyme
Alternate IDs
None
Definition
Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA. Source: RHEA:24404, EC:4.1.3.4
Comment
None
History
See term history for GO:0004419 at QuickGO
Chem. react.
has participant (3S)-3-hydroxy-3-methylglutaryl-CoA(5-)
has participant acetyl-CoA(4-)
has participant acetoacetate
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0004419 from QuickGO

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Parents of hydroxymethylglutaryl-CoA lyase activity (GO:0004419)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
hydroxymethylglutaryl-CoA lyase activity [RO:0000057 relation] RO:0000057  (3S)-3-hydroxy-3-methylglutaryl-CoA(5-) (CHEBI:43074)
hydroxymethylglutaryl-CoA lyase activity [RO:0000057 relation] RO:0000057  acetyl-CoA(4-) (CHEBI:57288)
hydroxymethylglutaryl-CoA lyase activity [RO:0000057 relation] RO:0000057  acetoacetate (CHEBI:13705)
hydroxymethylglutaryl-CoA lyase activity [is_a relation] is_a  oxo-acid-lyase activity (GO:0016833)

This term has no children.