AmiGO 2: Term Details for "hydroxymethylglutaryl-CoA reductase (NADPH) activity" (GO:0004420)

Accession: GO:0004420
Name: hydroxymethylglutaryl-CoA reductase (NADPH) activity
Ontology: molecular_function
Synonyms: hydroxymethylglutaryl-CoA reductase activity, 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, HMG-CoA reductase activity
Alternate IDs: GO:0042282
Definition: Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H+ + 2 NADPH. Source: RHEA:15989, PMID:29224355
Comment: None
History: See term history for GO:0004420 at QuickGO
Chem. react.: has participant NADPH(4-); has participant hydron; has participant coenzyme A(4-); has participant (R)-mevalonate; has participant (3S)-3-hydroxy-3-methylglutaryl-CoA(5-); has participant NADP(3-)
Subset: None
Related: Link to all genes and gene products annotated to hydroxymethylglutaryl-CoA reductase (NADPH) activity (excluding "regulates").; Link to all direct and indirect annotations to hydroxymethylglutaryl-CoA reductase (NADPH) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for hydroxymethylglutaryl-CoA reductase (NADPH) activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
hydroxymethylglutaryl-CoA reductase (NADPH) activity	is_a	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor (GO:0016616)
hydroxymethylglutaryl-CoA reductase (NADPH) activity	RO:0000057	NADPH(4-) (CHEBI:57783)
hydroxymethylglutaryl-CoA reductase (NADPH) activity	RO:0000057	hydron (CHEBI:15378)
hydroxymethylglutaryl-CoA reductase (NADPH) activity	RO:0000057	coenzyme A(4-) (CHEBI:57287)
hydroxymethylglutaryl-CoA reductase (NADPH) activity	RO:0000057	(R)-mevalonate (CHEBI:36464)
hydroxymethylglutaryl-CoA reductase (NADPH) activity	RO:0000057	(3S)-3-hydroxy-3-methylglutaryl-CoA(5-) (CHEBI:43074)
hydroxymethylglutaryl-CoA reductase (NADPH) activity	RO:0000057	NADP(3-) (CHEBI:58349)

This term has no children.