AmiGO 2: Term Details for "isocitrate dehydrogenase (NADP+) activity" (GO:0004450)

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Term Information

Accession: GO:0004450
Name: isocitrate dehydrogenase (NADP+) activity
Ontology: molecular_function
Synonyms: NADP isocitric dehydrogenase activity, NADP(+)-linked isocitrate dehydrogenase activity, NADP-dependent isocitrate dehydrogenase activity, NADP-dependent isocitric dehydrogenase activity, NADP-linked isocitrate dehydrogenase activity, NADP-specific isocitrate dehydrogenase activity, isocitrate (NADP) dehydrogenase activity, isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity, isocitrate dehydrogenase (NADP) activity, isocitrate dehydrogenase (NADP-dependent) activity, isocitrate:NADP+ oxidoreductase (decarboxylating), triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity, NADP(+)-ICDH activity, NADP(+)-IDH activity, dual-cofactor-specific isocitrate dehydrogenase activity
Alternate IDs: None
Definition: Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. Source: RHEA:19629
Comment: None
History: See term history for GO:0004450 at QuickGO
Chem. react.: has participant 2-oxoglutarate(2-); has participant D-threo-isocitrate(3-); has participant NADP(3-); has participant carbon dioxide; has participant NADPH(4-)
Subset: None
Related: Link to all genes and gene products annotated to isocitrate dehydrogenase (NADP+) activity (excluding "regulates").; Link to all direct and indirect annotations to isocitrate dehydrogenase (NADP+) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for isocitrate dehydrogenase (NADP+) activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016614 oxidoreductase activity, acting on CH-OH group of donors
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0004448 isocitrate dehydrogenase [NAD(P)+] activity
GO:0004450 isocitrate dehydrogenase (NADP+) activity

Parents of isocitrate dehydrogenase (NADP+) activity (GO:0004450)

subject	relation	object
isocitrate dehydrogenase (NADP+) activity	is_a	isocitrate dehydrogenase [NAD(P)+] activity (GO:0004448)
isocitrate dehydrogenase (NADP+) activity	RO:0000057	2-oxoglutarate(2-) (CHEBI:16810)
isocitrate dehydrogenase (NADP+) activity	RO:0000057	D-threo-isocitrate(3-) (CHEBI:15562)
isocitrate dehydrogenase (NADP+) activity	RO:0000057	NADP(3-) (CHEBI:58349)
isocitrate dehydrogenase (NADP+) activity	RO:0000057	carbon dioxide (CHEBI:16526)
isocitrate dehydrogenase (NADP+) activity	RO:0000057	NADPH(4-) (CHEBI:57783)

This term has no children.

EC: 1.1.1.42
MetaCyc: ISOCITDEH-RXN
Reactome: R-HSA-450984; R-HSA-389540; R-HSA-389550
RHEA: 19629