AmiGO 2: Term Details for "leukotriene-C4 synthase activity" (GO:0004464)

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Term Information

Accession: GO:0004464
Name: leukotriene-C4 synthase activity
Ontology: molecular_function
Synonyms: (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming), LTC(4) synthase activity, LTC(4) synthetase activity, LTC4 synthase activity, LTC4 synthetase activity, leukotriene A(4):glutathione S-leukotrienyltransferase activity, leukotriene A4:glutathione S-leukotrienyltransferase activity, leukotriene C(4) synthetase activity, leukotriene C4 synthetase activity, leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)
Alternate IDs: None
Definition: Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4). Source: EC:4.4.1.20, RHEA:17617
Comment: Note that this function was EC:2.5.1.37.
History: See term history for GO:0004464 at QuickGO
Chem. react.: has participant glutathionate(1-); has participant leukotriene C4(2-); has participant leukotriene A4(1-)
Subset: None
Related: Link to all genes and gene products annotated to leukotriene-C4 synthase activity (excluding "regulates").; Link to all direct and indirect annotations to leukotriene-C4 synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for leukotriene-C4 synthase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016829 lyase activity
GO:0016846 carbon-sulfur lyase activity
GO:0004464 leukotriene-C4 synthase activity

Parents of leukotriene-C4 synthase activity (GO:0004464)

subject	relation	object
leukotriene-C4 synthase activity	RO:0000057	glutathionate(1-) (CHEBI:57925)
leukotriene-C4 synthase activity	is_a	carbon-sulfur lyase activity (GO:0016846)
leukotriene-C4 synthase activity	RO:0000057	leukotriene C4(2-) (CHEBI:57973)
leukotriene-C4 synthase activity	RO:0000057	leukotriene A4(1-) (CHEBI:57463)

This term has no children.

EC: 4.4.1.20
KEGG_REACTION: R03059
MetaCyc: LEUKOTRIENE-C4-SYNTHASE-RXN
Reactome: R-HSA-266050
RHEA: 17617