AmiGO 2: Term Details for "methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity" (GO:0004491)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0004491
Name: methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity
Ontology: molecular_function
Synonyms: MMSA dehydrogenase activity, MSDH activity, methylmalonate-semialdehyde dehydrogenase (acylating) activity
Alternate IDs: None
Definition: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product. Source: PMID:2768248, EC:1.2.1.27
Comment: None
History: See term history for GO:0004491 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (excluding "regulates").; Link to all direct and indirect annotations to methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity

Parents of methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity (GO:0004491)

subject	relation	object
methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity	is_a	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor (GO:0016620)

This term has no children.

EC: 1.2.1.27
MetaCyc: 1.2.1.27-RXN
Reactome: R-HSA-70893
RHEA: 76615; 20804