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Accession
GO:0004504
Name
peptidylglycine monooxygenase activity
Ontology
molecular_function
Synonyms
peptidylglycine 2-hydroxylase activity, PAM activity, PAM-A, PAM-B, peptide alpha-amidating enzyme, peptide alpha-amide synthase activity, peptide-alpha-amide synthetase activity, peptidyl alpha-amidating enzyme activity, peptidylglycine alpha-amidating monooxygenase activity, peptidylglycine alpha-hydroxylase activity, peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating), synthase, peptide alpha-amide
Alternate IDs
None
Definition
Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O. Source: EC:1.14.17.3
Comment
None
History
See term history for GO:0004504 at QuickGO
Chem. react.
has participant water
has participant L-ascorbate
has participant C-terminal Xaa-Gly(1-) residue
has participant C-terminal Xaa-(2S)-hydroxyglycino(1-) residue
has participant monodehydro-L-ascorbate(1-)
has participant dioxygen
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of peptidylglycine monooxygenase activity (GO:0004504)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
peptidylglycine monooxygenase activity [RO:0000057 relation] RO:0000057  water (CHEBI:15377)
peptidylglycine monooxygenase activity [RO:0000057 relation] RO:0000057  L-ascorbate (CHEBI:38290)
peptidylglycine monooxygenase activity [RO:0000057 relation] RO:0000057  C-terminal Xaa-Gly(1-) residue (CHEBI:137000)
peptidylglycine monooxygenase activity [RO:0000057 relation] RO:0000057  C-terminal Xaa-(2S)-hydroxyglycino(1-) residue (CHEBI:142768)
peptidylglycine monooxygenase activity [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen (GO:0016715)
peptidylglycine monooxygenase activity [RO:0000057 relation] RO:0000057  monodehydro-L-ascorbate(1-) (CHEBI:59513)
peptidylglycine monooxygenase activity [RO:0000057 relation] RO:0000057  dioxygen (CHEBI:15379)

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