AmiGO 2: Term Details for "phenylalanine 4-monooxygenase activity" (GO:0004505)

Term Information

Accession: GO:0004505
Name: phenylalanine 4-monooxygenase activity
Ontology: molecular_function
Synonyms: phenylalanine hydroxylase activity, L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating), PAH activity, phenylalaninase activity, phenylalanine 4-hydroxylase activity
Alternate IDs: None
Definition: Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin. Source: PMID:4004813, RHEA:20273
Comment: None
History: See term history for GO:0004505 at QuickGO
Chem. react.: has participant L-phenylalanine zwitterion; has participant dioxygen; has participant 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin; has participant L-tyrosine zwitterion; has participant sapropterin
Subset: None
Related: Link to all genes and gene products annotated to phenylalanine 4-monooxygenase activity (excluding "regulates").; Link to all direct and indirect annotations to phenylalanine 4-monooxygenase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for phenylalanine 4-monooxygenase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0071704 organic substance metabolic process
GO:0044281 small molecule metabolic process
GO:0006520 amino acid metabolic process
GO:0019752 carboxylic acid metabolic process
GO:0044249 cellular biosynthetic process
GO:0006082 organic acid metabolic process
GO:1901576 organic substance biosynthetic process
GO:1901564 organonitrogen compound metabolic process
GO:0044283 small molecule biosynthetic process
GO:1901605 alpha-amino acid metabolic process
GO:0008652 amino acid biosynthetic process
GO:0046394 carboxylic acid biosynthetic process
GO:0016053 organic acid biosynthetic process
GO:1901360 organic cyclic compound metabolic process
GO:1901566 organonitrogen compound biosynthetic process
GO:0043436 oxoacid metabolic process
GO:0044238 primary metabolic process
GO:1901607 alpha-amino acid biosynthetic process
GO:0009072 aromatic amino acid metabolic process
GO:0170033 L-amino acid metabolic process
GO:0003674 molecular_function
GO:1901362 organic cyclic compound biosynthetic process
GO:0170039 proteinogenic amino acid metabolic process
GO:0009073 aromatic amino acid family biosynthetic process
GO:0003824 catalytic activity
GO:1902221 erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process
GO:0170034 L-amino acid biosynthetic process
GO:0170038 proteinogenic amino acid biosynthetic process
GO:0009095 aromatic amino acid family biosynthetic process, prephenate pathway
GO:1902223 erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process
GO:0016491 oxidoreductase activity
GO:0006570 tyrosine metabolic process
GO:0004497 monooxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0006571 tyrosine biosynthetic process
GO:0016714 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen
GO:0019293 tyrosine biosynthetic process, by oxidation of phenylalanine
GO:0004505 phenylalanine 4-monooxygenase activity

Parents of phenylalanine 4-monooxygenase activity (GO:0004505)

subject	relation	object
phenylalanine 4-monooxygenase activity	RO:0000057	L-phenylalanine zwitterion (CHEBI:58095)
phenylalanine 4-monooxygenase activity	BFO:0000050	tyrosine biosynthetic process, by oxidation of phenylalanine (GO:0019293)
phenylalanine 4-monooxygenase activity	is_a	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen (GO:0016714)
phenylalanine 4-monooxygenase activity	RO:0000057	dioxygen (CHEBI:15379)
phenylalanine 4-monooxygenase activity	RO:0000057	4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin (CHEBI:15642)
phenylalanine 4-monooxygenase activity	RO:0000057	L-tyrosine zwitterion (CHEBI:58315)
phenylalanine 4-monooxygenase activity	RO:0000057	sapropterin (CHEBI:59560)

This term has no children.

EC: 1.14.16.1
MetaCyc: RXN66-569
Reactome: R-HSA-71118; R-HSA-5649483
RHEA: 20273