AmiGO 2: Term Details for "squalene monooxygenase activity" (GO:0004506)

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Term Information

Accession: GO:0004506
Name: squalene monooxygenase activity
Ontology: molecular_function
Synonyms: squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity, squalene 2,3-oxidocyclase activity, squalene epoxidase activity, squalene hydroxylase activity, squalene oxydocyclase activity, squalene-2,3-epoxidase activity, squalene-2,3-epoxide cyclase activity
Alternate IDs: None
Definition: Catalysis of the reaction: H+ + NADPH + O2 + squalene = (S)-2,3-epoxysqualene + H2O + NADP+. Source: RHEA:25282
Comment: None
History: See term history for GO:0004506 at QuickGO
Chem. react.: has participant squalene; has participant (S)-2,3-epoxysqualene; has participant FMN(3-); has participant hydron; has participant FMNH2(2-); has participant dioxygen; has participant water
Subset: None
Related: Link to all genes and gene products annotated to squalene monooxygenase activity (excluding "regulates").; Link to all direct and indirect annotations to squalene monooxygenase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for squalene monooxygenase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0004497 monooxygenase activity
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0004506 squalene monooxygenase activity

Parents of squalene monooxygenase activity (GO:0004506)

subject	relation	object
squalene monooxygenase activity	RO:0000057	squalene (CHEBI:15440)
squalene monooxygenase activity	RO:0000057	(S)-2,3-epoxysqualene (CHEBI:15441)
squalene monooxygenase activity	RO:0000057	FMN(3-) (CHEBI:58210)
squalene monooxygenase activity	RO:0000057	hydron (CHEBI:15378)
squalene monooxygenase activity	is_a	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
squalene monooxygenase activity	RO:0000057	FMNH2(2-) (CHEBI:57618)
squalene monooxygenase activity	RO:0000057	dioxygen (CHEBI:15379)
squalene monooxygenase activity	RO:0000057	water (CHEBI:15377)

This term has no children.

EC: 1.14.14.17
KEGG_REACTION: R02874
MetaCyc: SQUALENE-MONOOXYGENASE-RXN
Reactome: R-HSA-191299
RHEA: 25282