Term Information

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Accession
GO:0004511
Name
tyrosine 3-monooxygenase activity
Ontology
molecular_function
Synonyms
tyrosine 3-hydroxylase activity, tyrosine hydroxylase activity, L-tyrosine hydroxylase activity, L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)
Alternate IDs
None
Definition
Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O. Source: EC:1.14.16.2
Comment
None
History
See term history for GO:0004511 at QuickGO
Chem. react.
has participant L-dopa zwitterion
has participant L-tyrosine zwitterion
has participant dioxygen
has participant sapropterin
has participant 4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0004511 from QuickGO

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Parents of tyrosine 3-monooxygenase activity (GO:0004511)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
tyrosine 3-monooxygenase activity [RO:0000057 relation] RO:0000057  L-dopa zwitterion (CHEBI:57504)
tyrosine 3-monooxygenase activity [RO:0000057 relation] RO:0000057  L-tyrosine zwitterion (CHEBI:58315)
tyrosine 3-monooxygenase activity [RO:0000057 relation] RO:0000057  dioxygen (CHEBI:15379)
tyrosine 3-monooxygenase activity [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen (GO:0016714)
tyrosine 3-monooxygenase activity [RO:0000057 relation] RO:0000057  sapropterin (CHEBI:59560)
tyrosine 3-monooxygenase activity [RO:0000057 relation] RO:0000057  4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin (CHEBI:15642)
Children of tyrosine 3-monooxygenase activity (GO:0004511)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of tyrosine 3-monooxygenase activity (GO:1903178) [RO:0002213 relation] RO:0002213  tyrosine 3-monooxygenase activity
negative regulation of tyrosine 3-monooxygenase activity (GO:1903177) [RO:0002212 relation] RO:0002212  tyrosine 3-monooxygenase activity
tyrosine 3-monooxygenase activator activity (GO:0036470) [RO:0002629 relation] RO:0002629  tyrosine 3-monooxygenase activity
regulation of tyrosine 3-monooxygenase activity (GO:1903176) [RO:0002211 relation] RO:0002211  tyrosine 3-monooxygenase activity