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nitric-oxide synthase activity

Term Information

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Accession
GO:0004517
Name
nitric-oxide synthase activity
Ontology
molecular_function
Synonyms
nitric oxide synthase activity, L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity, NADPH-diaphorase activity, NO synthase activity, endothelium-derived relaxation factor-forming enzyme activity, endothelium-derived relaxing factor synthase activity, nitric oxide synthetase activity, nitric-oxide synthetase activity
Alternate IDs
None
Definition
Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+. Source: EC:1.14.13.39, RHEA:19897
Comment
None
History
See term history for GO:0004517 at QuickGO
Chem. react.
has participant L-argininium(1+)
has participant water
has participant NADPH(4-)
has participant dioxygen
has participant L-citrulline zwitterion
has participant NADP(3-)
has participant hydron
has participant nitric oxide
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of nitric-oxide synthase activity (GO:0004517)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  L-argininium(1+) (CHEBI:32682)
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  water (CHEBI:15377)
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  NADPH(4-) (CHEBI:57783)
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  dioxygen (CHEBI:15379)
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  L-citrulline zwitterion (CHEBI:57743)
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  NADP(3-) (CHEBI:58349)
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
nitric-oxide synthase activity [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
nitric-oxide synthase activity [RO:0000057 relation] RO:0000057  nitric oxide (CHEBI:16480)
Children of nitric-oxide synthase activity (GO:0004517)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
positive regulation of nitric-oxide synthase activity (GO:0051000) [RO:0002213 relation] RO:0002213  nitric-oxide synthase activity
nitric-oxide synthase complex (GO:1903958) [RO:0002215 relation] RO:0002215  nitric-oxide synthase activity
nitric-oxide synthase regulator activity (GO:0030235) [RO:0002578 relation] RO:0002578  nitric-oxide synthase activity
nitric-oxide synthase inhibitor activity (GO:0036487) [RO:0002630 relation] RO:0002630  nitric-oxide synthase activity
negative regulation of nitric-oxide synthase activity (GO:0051001) [RO:0002212 relation] RO:0002212  nitric-oxide synthase activity
regulation of nitric-oxide synthase activity (GO:0050999) [RO:0002211 relation] RO:0002211  nitric-oxide synthase activity