AmiGO 2: Term Details for "RNA-DNA hybrid ribonuclease activity" (GO:0004523)

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Term Information

Accession: GO:0004523
Name: RNA-DNA hybrid ribonuclease activity
Ontology: molecular_function
Synonyms: RNase H activity, calf thymus ribonuclease H activity, ribonuclease H activity, RNA*DNA hybrid ribonucleotidohydrolase activity, endoribonuclease H, endoribonuclease H (calf thymus), hybrid nuclease activity, hybrid ribonuclease activity, hybridase (ribonuclease H), hybridase activity, RNase H1 activity, RNase H2 activity, RNase H3 activity, endoribonuclease0 H activity, ribonuclease H1 activity, ribonuclease H2 activity, ribonuclease H3 activity
Alternate IDs: GO:0004524
Definition: Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters. Source: EC:3.1.26.4
Comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species.
History: See term history for GO:0004523 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to RNA-DNA hybrid ribonuclease activity (excluding "regulates").; Link to all direct and indirect annotations to RNA-DNA hybrid ribonuclease activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for RNA-DNA hybrid ribonuclease activity (excluding "regulates").

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GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016787 hydrolase activity
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0016788 hydrolase activity, acting on ester bonds
GO:0140098 catalytic activity, acting on RNA
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004540 RNA nuclease activity
GO:0016893 endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters
GO:0004521 RNA endonuclease activity
GO:0016891 RNA endonuclease activity, producing 5'-phosphomonoesters
GO:0004523 RNA-DNA hybrid ribonuclease activity

Parents of RNA-DNA hybrid ribonuclease activity (GO:0004523)

subject	relation	object
RNA-DNA hybrid ribonuclease activity	is_a	RNA endonuclease activity, producing 5'-phosphomonoesters (GO:0016891)

This term has no children.

EC: 3.1.26.4
MetaCyc: 3.1.26.4-RXN
Reactome: R-HSA-182795; R-HSA-173769; R-HSA-164528; R-HSA-164519; R-HSA-182859