AmiGO 2: Term Details for "glutathione peroxidase activity" (GO:0004602)

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Term Information

Accession: GO:0004602
Name: glutathione peroxidase activity
Ontology: molecular_function
Synonyms: GSH peroxidase activity, glutathione:hydrogen-peroxide oxidoreductase activity, reduced glutathione peroxidase activity, selenium-glutathione peroxidase activity, non-selenium glutathione peroxidase activity
Alternate IDs: GO:0016224
Definition: Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O. Source: PMID:36771108, EC:1.11.1.9
Comment: None
History: See term history for GO:0004602 at QuickGO
Chem. react.: has participant water; has participant hydrogen peroxide; has participant glutathionate(1-); has participant glutathione disulfide(2-)
Subset: None
Related: Link to all genes and gene products annotated to glutathione peroxidase activity (excluding "regulates").; Link to all direct and indirect annotations to glutathione peroxidase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for glutathione peroxidase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
GO:0008150 biological_process
UBERON:0001062 anatomical entity
GO:0009987 cellular process
CARO:0000006 material anatomical entity
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0042221 response to chemical
UBERON:0000061 anatomical structure
GO:0070887 cellular response to chemical stimulus
GO:0009636 response to toxic substance
CL:0000000 cell
GO:0097237 cellular response to toxic substance
GO:0098754 detoxification
GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:1990748 cellular detoxification
GO:0098869 cellular oxidant detoxification
GO:0016491 oxidoreductase activity
GO:0016209 antioxidant activity
GO:0016684 oxidoreductase activity, acting on peroxide as acceptor
GO:0004601 peroxidase activity
GO:0004602 glutathione peroxidase activity
GO:1903283 negative regulation of glutathione peroxidase activity
GO:1903284 positive regulation of glutathione peroxidase activity
GO:1903282 regulation of glutathione peroxidase activity

Parents of glutathione peroxidase activity (GO:0004602)

subject	relation	object
glutathione peroxidase activity	RO:0000057	water (CHEBI:15377)
glutathione peroxidase activity	is_a	peroxidase activity (GO:0004601)
glutathione peroxidase activity	RO:0000057	hydrogen peroxide (CHEBI:16240)
glutathione peroxidase activity	RO:0000057	glutathionate(1-) (CHEBI:57925)
glutathione peroxidase activity	RO:0000057	glutathione disulfide(2-) (CHEBI:58297)

Children of glutathione peroxidase activity (GO:0004602)

subject	relation	object
positive regulation of glutathione peroxidase activity (GO:1903284)	RO:0002213	glutathione peroxidase activity
regulation of glutathione peroxidase activity (GO:1903282)	RO:0002211	glutathione peroxidase activity
negative regulation of glutathione peroxidase activity (GO:1903283)	RO:0002212	glutathione peroxidase activity

EC: 1.11.1.9
MetaCyc: GLUTATHIONE-PEROXIDASE-RXN
Reactome: R-HSA-2161999; R-HSA-2161946; R-HSA-2161959; R-HSA-3343700; R-HSA-71676; R-HSA-6799695; R-HSA-3323013; R-HSA-3341277; R-HSA-2161791; R-HSA-3341397
RHEA: 16833