AmiGO 2: Term Details for "phosphoribosylformylglycinamidine synthase activity" (GO:0004642)

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Term Information

Accession: GO:0004642
Name: phosphoribosylformylglycinamidine synthase activity
Ontology: molecular_function
Synonyms: 2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming), 5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming), FGAM synthase activity, FGAM synthetase activity, FGAR amidotransferase activity, FGARAT activity, N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming), formylglycinamide ribonucloetide amidotransferase activity, formylglycinamide ribotide amidotransferase activity, phosphoribosylformylglycinamidine synthetase activity, phosphoribosylformylglycineamidine synthetase activity
Alternate IDs: None
Definition: Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate. Source: EC:6.3.5.3, RHEA:17129
Comment: None
History: See term history for GO:0004642 at QuickGO
Chem. react.: has participant 2-formamido-N(1)-(5-O-phosphonato-beta-D-ribosyl)acetamidine; has participant hydron; has participant water; has participant L-glutamine zwitterion; has participant N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-); has participant hydrogenphosphate; has participant ATP(4-); has participant ADP(3-); has participant L-glutamate(1-)
Subset: None
Related: Link to all genes and gene products annotated to phosphoribosylformylglycinamidine synthase activity (excluding "regulates").; Link to all direct and indirect annotations to phosphoribosylformylglycinamidine synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for phosphoribosylformylglycinamidine synthase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016874 ligase activity
GO:0016879 ligase activity, forming carbon-nitrogen bonds
GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor
GO:0004642 phosphoribosylformylglycinamidine synthase activity

Parents of phosphoribosylformylglycinamidine synthase activity (GO:0004642)

subject	relation	object
phosphoribosylformylglycinamidine synthase activity	RO:0000057	2-formamido-N(1)-(5-O-phosphonato-beta-D-ribosyl)acetamidine (CHEBI:147287)
phosphoribosylformylglycinamidine synthase activity	is_a	carbon-nitrogen ligase activity, with glutamine as amido-N-donor (GO:0016884)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	hydron (CHEBI:15378)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	water (CHEBI:15377)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	L-glutamine zwitterion (CHEBI:58359)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	N(2)-formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide(2-) (CHEBI:147286)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	hydrogenphosphate (CHEBI:43474)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	ATP(4-) (CHEBI:30616)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	ADP(3-) (CHEBI:456216)
phosphoribosylformylglycinamidine synthase activity	RO:0000057	L-glutamate(1-) (CHEBI:29985)

This term has no children.

EC: 6.3.5.3
KEGG_REACTION: R04463
MetaCyc: FGAMSYN-RXN
Reactome: R-HSA-73812
RHEA: 17129