AmiGO 2: Term Details for "protein-arginine deiminase activity" (GO:0004668)

Accession: GO:0004668
Name: protein-arginine deiminase activity
Ontology: molecular_function
Synonyms: peptidylarginine deiminase activity, protein-L-arginine iminohydrolase activity
Alternate IDs: None
Definition: Catalysis of the reaction: H2O + L-arginyl-[protein] = L-citrullyl-[protein] + NH4+, resulting in citrullination of the target protein. This reaction is calcium-dependent. Source: PMID:27393304
Comment: None
History: See term history for GO:0004668 at QuickGO
Chem. react.: has participant ammonium; has participant L-citrulline residue; has participant water; has participant L-argininium residue
Subset: None
Related: Link to all genes and gene products annotated to protein-arginine deiminase activity (excluding "regulates").; Link to all direct and indirect annotations to protein-arginine deiminase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for protein-arginine deiminase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
protein-arginine deiminase activity	RO:0000057	ammonium (CHEBI:28938)
protein-arginine deiminase activity	is_a	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines (GO:0016813)
protein-arginine deiminase activity	RO:0000057	L-citrulline residue (CHEBI:83397)
protein-arginine deiminase activity	RO:0000057	water (CHEBI:15377)
protein-arginine deiminase activity	RO:0000057	L-argininium residue (CHEBI:29965)

subject	relation	object
histone arginine deiminase activity (GO:0140794)	is_a	protein-arginine deiminase activity