AmiGO 2: Term Details for "MAP kinase kinase activity" (GO:0004708)

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Term Information

Accession: GO:0004708
Name: MAP kinase kinase activity
Ontology: molecular_function
Synonyms: ERK activator kinase activity, MAPK activator activity, MAPKK activity, ATP:protein phosphotransferase (MAPKKK-activated) activity, MAP kinase or ERK kinase activity, MAP2K, MAPKK, MAPKK1, MEK1, MEK2, MKK, MKK2, MKK4, MKK6, MKK7, STK27, mitogen-activated protein kinase kinase activity, MAP kinase kinase 4 activity, MAP kinase kinase 7 activity, MEK activity
Alternate IDs: None
Definition: Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate. Source: ISBN:0198547684
Comment: None
History: See term history for GO:0004708 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to MAP kinase kinase activity (excluding "regulates").; Link to all direct and indirect annotations to MAP kinase kinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for MAP kinase kinase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0003824 catalytic activity
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0051716 cellular response to stimulus
GO:0003674 molecular_function
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0016740 transferase activity
GO:0005622 intracellular anatomical structure
GO:0007165 signal transduction
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0140096 catalytic activity, acting on a protein
GO:0035556 intracellular signal transduction
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0141124 intracellular signaling cassette
GO:0004672 protein kinase activity
GO:0000165 MAPK cascade
GO:0004712 protein serine/threonine/tyrosine kinase activity
GO:0004708 MAP kinase kinase activity
GO:0008545 JUN kinase kinase activity

Parents of MAP kinase kinase activity (GO:0004708)

subject	relation	object
MAP kinase kinase activity	BFO:0000050	MAPK cascade (GO:0000165)
MAP kinase kinase activity	RO:0002162	Eukaryota (NCBITaxon:2759)
MAP kinase kinase activity	is_a	protein serine/threonine/tyrosine kinase activity (GO:0004712)

Children of MAP kinase kinase activity (GO:0004708)

subject	relation	object
JUN kinase kinase activity (GO:0008545)	is_a	MAP kinase kinase activity

EC: 2.7.12.2
MetaCyc: 2.7.12.2-RXN
Reactome: R-HSA-1247960; R-HSA-448951; R-HSA-3238999; R-HSA-5218804; R-HSA-450333