AmiGO 2: Term Details for "thioredoxin-disulfide reductase (NADPH) activity" (GO:0004791)

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Term Information

Accession: GO:0004791
Name: thioredoxin-disulfide reductase (NADPH) activity
Ontology: molecular_function
Synonyms: NADPH:oxidized thioredoxin oxidoreductase activity, thioredoxin reductase (NADPH) activity, thioredoxin-disulfide reductase (NADP) activity, thioredoxin disulfide reductase activity, thioredoxin-disulfide reductase activity, thioredoxin-disulphide reductase activity
Alternate IDs: None
Definition: Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. Source: RHEA:20345
Comment: None
History: See term history for GO:0004791 at QuickGO
Chem. react.: has participant NADP(3-); has participant L-cystine residue; has participant hydron; has participant NADPH(4-); has participant L-cysteine residue
Subset: None
Related: Link to all genes and gene products annotated to thioredoxin-disulfide reductase (NADPH) activity (excluding "regulates").; Link to all direct and indirect annotations to thioredoxin-disulfide reductase (NADPH) activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for thioredoxin-disulfide reductase (NADPH) activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
GO:0008150 biological_process
UBERON:0001062 anatomical entity
GO:0009987 cellular process
CARO:0000006 material anatomical entity
GO:0050896 response to stimulus
GO:0051716 cellular response to stimulus
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0042221 response to chemical
UBERON:0000061 anatomical structure
GO:0003824 catalytic activity
GO:0070887 cellular response to chemical stimulus
GO:0003674 molecular_function
GO:0009636 response to toxic substance
CL:0000000 cell
GO:0097237 cellular response to toxic substance
GO:0098754 detoxification
GO:0016491 oxidoreductase activity
GO:0016667 oxidoreductase activity, acting on a sulfur group of donors
GO:0140096 catalytic activity, acting on a protein
GO:1990748 cellular detoxification
GO:0015036 disulfide oxidoreductase activity
GO:0098869 cellular oxidant detoxification
GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
GO:0015035 protein-disulfide reductase activity
GO:0016209 antioxidant activity
GO:0047134 protein-disulfide reductase (NAD(P)H) activity
GO:0004791 thioredoxin-disulfide reductase (NADPH) activity
GO:1902515 thioredoxin-disulfide reductase complex

Parents of thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)

subject	relation	object
thioredoxin-disulfide reductase (NADPH) activity	RO:0000057	NADP(3-) (CHEBI:58349)
thioredoxin-disulfide reductase (NADPH) activity	RO:0000057	L-cystine residue (CHEBI:50058)
thioredoxin-disulfide reductase (NADPH) activity	RO:0000057	hydron (CHEBI:15378)
thioredoxin-disulfide reductase (NADPH) activity	is_a	antioxidant activity (GO:0016209)
thioredoxin-disulfide reductase (NADPH) activity	is_a	protein-disulfide reductase (NAD(P)H) activity (GO:0047134)
thioredoxin-disulfide reductase (NADPH) activity	RO:0000057	NADPH(4-) (CHEBI:57783)
thioredoxin-disulfide reductase (NADPH) activity	RO:0000057	L-cysteine residue (CHEBI:29950)

Children of thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)

subject	relation	object
thioredoxin-disulfide reductase complex (GO:1902515)	RO:0002215	thioredoxin-disulfide reductase (NADPH) activity

EC: 1.8.1.9
KEGG_REACTION: R02016
MetaCyc: THIOREDOXIN-REDUCT-NADPH-RXN
Reactome: R-HSA-1222485; R-HSA-9617735; R-HSA-3323050; R-HSA-73646
RHEA: 20345