AmiGO 2: Term Details for "thyroxine 5'-deiodinase activity" (GO:0004800)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0004800
Name: thyroxine 5'-deiodinase activity
Ontology: molecular_function
Synonyms: outer ring-deiodinating pathway, thyroxine 5' deiodinase activity, L-thyroxine iodohydrolase (reducing) activity, acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating), diiodothyronine 5'-deiodinase activity, iodothyronine 5'-deiodinase activity, iodothyronine outer ring monodeiodinase activity, type I iodothyronine deiodinase activity, type II iodothyronine deiodinase activity, thyroxine deiodinase activity
Alternate IDs: None
Definition: Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2. Source: EC:1.21.99.4
Comment: Note that this was EC:3.8.1.4.
History: See term history for GO:0004800 at QuickGO
Chem. react.: has participant 3,3',5-triiodo-L-thyronine zwitterion; has participant hydrogen donor; has participant iodide; has participant hydrogen acceptor; has participant L-thyroxine zwitterion; has participant hydron
Subset: None
Related: Link to all genes and gene products annotated to thyroxine 5'-deiodinase activity (excluding "regulates").; Link to all direct and indirect annotations to thyroxine 5'-deiodinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for thyroxine 5'-deiodinase activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0004800 thyroxine 5'-deiodinase activity

Parents of thyroxine 5'-deiodinase activity (GO:0004800)

subject	relation	object
thyroxine 5'-deiodinase activity	RO:0000057	3,3',5-triiodo-L-thyronine zwitterion (CHEBI:533015)
thyroxine 5'-deiodinase activity	RO:0000057	hydrogen donor (CHEBI:17499)
thyroxine 5'-deiodinase activity	RO:0000057	iodide (CHEBI:16382)
thyroxine 5'-deiodinase activity	RO:0000057	hydrogen acceptor (CHEBI:13193)
thyroxine 5'-deiodinase activity	RO:0000057	L-thyroxine zwitterion (CHEBI:58448)
thyroxine 5'-deiodinase activity	is_a	oxidoreductase activity (GO:0016491)
thyroxine 5'-deiodinase activity	RO:0000057	hydron (CHEBI:15378)

This term has no children.

EC: 1.21.99.4
MetaCyc: THYROXINE-DEIODINASE-RXN
Reactome: R-HSA-209772; R-HSA-350869
RHEA: 19745