Term Information

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Accession
GO:0004844
Name
uracil DNA N-glycosylase activity
Ontology
molecular_function
Synonyms
uracil-DNA glycosylase activity
Alternate IDs
None
Definition
Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine. Source: PMID:9224623, GOC:pr, GOC:elh
Comment
None
History
See term history for GO:0004844 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0004844 from QuickGO

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Parents of uracil DNA N-glycosylase activity (GO:0004844)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
uracil DNA N-glycosylase activity [is_a relation] is_a  deaminated base DNA N-glycosylase activity (GO:0097506)
Children of uracil DNA N-glycosylase activity (GO:0004844)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
G/U mismatch-specific uracil-DNA glycosylase activity (GO:0043739) [is_a relation] is_a  uracil DNA N-glycosylase activity
single-strand selective uracil DNA N-glycosylase activity (GO:0017065) [is_a relation] is_a  uracil DNA N-glycosylase activity
EC
3.2.2.27
https
//github.com/geneontology/go-ontology/issues/25051
Reactome
R-HSA-110215
R-HSA-110217