AmiGO 2: Term Details for "ureidoglycolate hydrolase activity" (GO:0004848)

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Term Information

Accession: GO:0004848
Name: ureidoglycolate hydrolase activity
Ontology: molecular_function
Synonyms: ureidoglycolate amidohydrolase activity
Alternate IDs: None
Definition: Catalysis of the reaction: (S)-ureidoglycolate + H2O + 2 H+ = CO2 + glyoxylate + 2 NH4. Source: RHEA:19809
Comment: Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC:3.5.1.116, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC:3.5.1.116) is a ureidoglycolate lyase, releasing urea (EC:4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC:3.5.1.116 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name.
History: See term history for GO:0004848 at QuickGO
Chem. react.: has participant water; has participant carbon dioxide; has participant glyoxylate; has participant hydron; has participant (-)-ureidoglycolate; has participant ammonium
Subset: None
Related: Link to all genes and gene products annotated to ureidoglycolate hydrolase activity (excluding "regulates").; Link to all direct and indirect annotations to ureidoglycolate hydrolase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for ureidoglycolate hydrolase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016787 hydrolase activity
GO:0016810 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0004848 ureidoglycolate hydrolase activity

Parents of ureidoglycolate hydrolase activity (GO:0004848)

subject	relation	object
ureidoglycolate hydrolase activity	RO:0000057	water (CHEBI:15377)
ureidoglycolate hydrolase activity	RO:0000057	carbon dioxide (CHEBI:16526)
ureidoglycolate hydrolase activity	RO:0000057	glyoxylate (CHEBI:36655)
ureidoglycolate hydrolase activity	RO:0000057	hydron (CHEBI:15378)
ureidoglycolate hydrolase activity	RO:0000057	(-)-ureidoglycolate (CHEBI:57296)
ureidoglycolate hydrolase activity	is_a	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811)
ureidoglycolate hydrolase activity	RO:0000057	ammonium (CHEBI:28938)

This term has no children.

EC: 3.5.1.116
KEGG_REACTION: R00469
MetaCyc: UREIDOGLYCOLATE-HYDROLASE-RXN
RHEA: 19809