AmiGO 2: Term Details for "nuclear receptor activity" (GO:0004879)

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Term Information

Accession: GO:0004879
Name: nuclear receptor activity
Ontology: molecular_function
Synonyms: RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding, ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity, ligand-dependent nuclear receptor activity, ligand-dependent transcription factor activity, 1,25-(OH)2D3 receptor activity, 9-cis retinoic acid receptor activity, RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding, RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding, RXR, androgen receptor activity, calcitriol receptor activity, ecdysteroid hormone receptor activity, estrogen nuclear receptor activity, glucocorticoid receptor activity, juvenile hormone receptor activity, nuclear hormone receptor, retinoic acid receptor activity, retinoid-X receptor activity, thyroid hormone receptor activity, vitamin A receptor activity, vitamin D receptor activity, vitamin D3 receptor activity
Alternate IDs: GO:0038052, GO:0038050, GO:0038051, GO:0004886, GO:0004887, GO:0004884, GO:0004882, GO:0004880, GO:0003708, GO:0008434
Definition: A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. Source: PMID:23457262, GOC:txnOH-2018
Comment: Usage guidance: Nuclear receptors are a protein family defined by the presence of a C4-type zinc finger DNA-binding domain and a ligand binding domain. For nuclear receptors, the DNA binding motif is most often referred to as a response element. GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'GO:0030374 ; nuclear receptor transcription coactivator activity' or GO:0140536 ; nuclear corepressor activity.
History: See term history for GO:0004879 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to nuclear receptor activity (excluding "regulates").; Link to all direct and indirect annotations to nuclear receptor activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for nuclear receptor activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
GO:0008150 biological_process
GO:0044237 cellular metabolic process
GO:0009987 cellular process
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0008152 metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
UBERON:0000061 anatomical structure
GO:0009058 biosynthetic process
GO:0006725 cellular aromatic compound metabolic process
GO:0044249 cellular biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0005575 cellular_component
GO:0046483 heterocycle metabolic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044238 primary metabolic process
GO:0050789 regulation of biological process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
GO:0019438 aromatic compound biosynthetic process
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0018130 heterocycle biosynthetic process
GO:0090304 nucleic acid metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:0009889 regulation of biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0051171 regulation of nitrogen compound metabolic process
GO:0080090 regulation of primary metabolic process
GO:0005622 intracellular anatomical structure
GO:0009059 macromolecule biosynthetic process
GO:0141187 nucleic acid biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0043226 organelle
GO:0031326 regulation of cellular biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
GO:0065007 biological regulation
GO:0010467 gene expression
GO:0043229 intracellular organelle
GO:0043228 non-membrane-bounded organelle
PR:000050567 protein-containing material entity
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051252 regulation of RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0006351 DNA-templated transcription
GO:0043232 intracellular non-membrane-bounded organelle
GO:0003674 molecular_function
GO:0032991 protein-containing complex
GO:0010468 regulation of gene expression
GO:2001141 regulation of RNA biosynthetic process
GO:0050896 response to stimulus
GO:0007154 cell communication
GO:0051716 cellular response to stimulus
GO:0005694 chromosome
GO:0032993 protein-DNA complex
GO:0006355 regulation of DNA-templated transcription
GO:0023052 signaling
GO:0006366 transcription by RNA polymerase II
GO:0140110 transcription regulator activity
GO:0000785 chromatin
GO:0003700 DNA-binding transcription factor activity
GO:0060089 molecular transducer activity
GO:0006357 regulation of transcription by RNA polymerase II
GO:0007165 signal transduction
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0030522 intracellular receptor signaling pathway
GO:0098531 ligand-activated transcription factor activity
GO:0038023 signaling receptor activity
GO:0004879 nuclear receptor activity
GO:0038186 bile acid nuclear receptor activity
GO:2000825 positive regulation of androgen receptor activity

Parents of nuclear receptor activity (GO:0004879)

subject	relation	object
nuclear receptor activity	is_a	DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)
nuclear receptor activity	is_a	signaling receptor activity (GO:0038023)
nuclear receptor activity	is_a	ligand-activated transcription factor activity (GO:0098531)
nuclear receptor activity	BFO:0000050	intracellular receptor signaling pathway (GO:0030522)

Children of nuclear receptor activity (GO:0004879)

subject	relation	object
bile acid nuclear receptor activity (GO:0038186)	is_a	nuclear receptor activity
positive regulation of androgen receptor activity (GO:2000825)	RO:0002213	nuclear receptor activity

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