Term Information

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Accession
GO:0005260
Name
intracellularly ATP-gated chloride channel activity
Ontology
molecular_function
Synonyms
CFTR, channel-conductance-controlling ATPase activity, cystic fibrosis transmembrane conductance regulator
Alternate IDs
GO:0005224
Definition
Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane. Source: PMID:9922375, PMID:24727426
Comment
This activity is a phosphorylation and ATP-gated anion channel, increasing the conductance for certain anions (e.g. Cl-) to flow down their electrochemical gradient. ATP-driven conformational changes in CFTR open and close a gate to allow transmembrane flow of anions down their electrochemical gradient.This in contrast to other ABC proteins, in which ATP-driven conformational changes fuel uphill substrate transport across cellular membranes. Essentially, CFTR is an ion channel that evolved as a 'broken' ABC transporter that leaks when in open conformation (from Wikipedia:Cystic_fibrosis_transmembrane_conductance_regulator).
History
See term history for GO:0005260 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of intracellularly ATP-gated chloride channel activity (GO:0005260)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
intracellularly ATP-gated chloride channel activity [is_a relation] is_a  ligand-gated monoatomic anion channel activity (GO:0099095)
intracellularly ATP-gated chloride channel activity [is_a relation] is_a  intracellularly ATP-gated ion channel activity (GO:0099142)
intracellularly ATP-gated chloride channel activity [RO:0004009 relation] RO:0004009  chloride (CHEBI:17996)
intracellularly ATP-gated chloride channel activity [is_a relation] is_a  chloride channel activity (GO:0005254)

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