AmiGO 2: Term Details for "signal recognition particle, endoplasmic reticulum targeting" (GO:0005786)

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Term Information

Accession: GO:0005786
Name: signal recognition particle, endoplasmic reticulum targeting
Ontology: cellular_component
Synonyms: SRP, signal sequence receptor complex
Alternate IDs: GO:0005855
Definition: A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana. Source: ISBN:0198506732, GOC:mtg_sensu
Comment: None
History: See term history for GO:0005786 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to signal recognition particle, endoplasmic reticulum targeting (excluding "regulates").; Link to all direct and indirect annotations to signal recognition particle, endoplasmic reticulum targeting (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for signal recognition particle, endoplasmic reticulum targeting (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
UBERON:0000061 anatomical structure
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0005575 cellular_component
PR:000050567 protein-containing material entity
GO:0005622 intracellular anatomical structure
GO:0032991 protein-containing complex
GO:0005737 cytoplasm
GO:1990904 ribonucleoprotein complex
GO:0048500 signal recognition particle
GO:0005786 signal recognition particle, endoplasmic reticulum targeting

Parents of signal recognition particle, endoplasmic reticulum targeting (GO:0005786)

subject	relation	object
signal recognition particle, endoplasmic reticulum targeting	is_a	signal recognition particle (GO:0048500)
signal recognition particle, endoplasmic reticulum targeting	RO:0002162	Eukaryota (NCBITaxon:2759)

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Wikipedia: Signal_recognition_particle