AmiGO 2: Term Details for "eukaryotic translation initiation factor 3 complex" (GO:0005852)

Accession: GO:0005852
Name: eukaryotic translation initiation factor 3 complex
Ontology: cellular_component
Synonyms: eIF-3, eIF3
Alternate IDs: None
Definition: A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs. Source: PMID:15904532
Comment: None
History: See term history for GO:0005852 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to eukaryotic translation initiation factor 3 complex (excluding "regulates").; Link to all direct and indirect annotations to eukaryotic translation initiation factor 3 complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for eukaryotic translation initiation factor 3 complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
eukaryotic translation initiation factor 3 complex	BFO:0000050	cytoplasm (GO:0005737)
eukaryotic translation initiation factor 3 complex	RO:0002160	Eukaryota (NCBITaxon:2759)
eukaryotic translation initiation factor 3 complex	is_a	protein-containing complex (GO:0032991)

subject	relation	object
eukaryotic translation initiation factor 3 complex, eIF3m (GO:0071541)	is_a	eukaryotic translation initiation factor 3 complex
eukaryotic translation initiation factor 3 complex assembly (GO:0070196)	RO:0002588	eukaryotic translation initiation factor 3 complex
eukaryotic translation initiation factor 3 complex, eIF3e (GO:0071540)	is_a	eukaryotic translation initiation factor 3 complex

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