AmiGO 2: Term Details for "tricarboxylic acid cycle" (GO:0006099)

Accession: GO:0006099
Name: tricarboxylic acid cycle
Ontology: biological_process
Synonyms: Krebs cycle, TCA cycle, citric acid cycle
Alternate IDs: None
Definition: A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. Source: ISBN:0198506732
Comment: None
History: See term history for GO:0006099 at QuickGO
Chem. react.: has participant citrate(3-)
Subset: None
Related: Link to all genes and gene products annotated to tricarboxylic acid cycle (excluding "regulates").; Link to all direct and indirect annotations to tricarboxylic acid cycle (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for tricarboxylic acid cycle (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

subject	relation	object
tricarboxylic acid cycle	BFO:0000050	aerobic respiration (GO:0009060)
tricarboxylic acid cycle	is_a	primary metabolic process (GO:0044238)
tricarboxylic acid cycle	RO:0000057	citrate(3-) (CHEBI:16947)

subject	relation	object
reductive tricarboxylic acid cycle (GO:0019643)	is_a	tricarboxylic acid cycle