AmiGO 2: Term Details for "lagging strand elongation" (GO:0006273)

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Term Information

Accession: GO:0006273
Name: lagging strand elongation
Ontology: biological_process
Synonyms: None
Alternate IDs: None
Definition: The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork. Source: GOC:mah, ISBN:0815316194, ISBN:071673706X
Comment: None
History: See term history for GO:0006273 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to lagging strand elongation (excluding "regulates").; Link to all direct and indirect annotations to lagging strand elongation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for lagging strand elongation (excluding "regulates").

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:0044238 primary metabolic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0006259 DNA metabolic process
GO:0090304 nucleic acid metabolic process
GO:0006260 DNA replication
GO:0022616 DNA strand elongation
GO:0006261 DNA-templated DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0006273 lagging strand elongation
GO:0033567 DNA replication, Okazaki fragment processing
GO:0090629 lagging strand initiation
GO:1903459 mitotic DNA replication lagging strand elongation

Parents of lagging strand elongation (GO:0006273)

subject	relation	object
lagging strand elongation	BFO:0000051	DNA replication, removal of RNA primer (GO:0043137)
lagging strand elongation	is_a	DNA strand elongation involved in DNA replication (GO:0006271)
lagging strand elongation	BFO:0000051	DNA replication, synthesis of primer (GO:0006269)

Children of lagging strand elongation (GO:0006273)

subject	relation	object
lagging strand initiation (GO:0090629)	BFO:0000050	lagging strand elongation
mitotic DNA replication lagging strand elongation (GO:1903459)	is_a	lagging strand elongation
DNA replication, Okazaki fragment processing (GO:0033567)	BFO:0000050	lagging strand elongation

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