AmiGO 2: Term Details for "apoptotic DNA fragmentation" (GO:0006309)

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Term Information

Accession: GO:0006309
Name: apoptotic DNA fragmentation
Ontology: biological_process
Synonyms: DNA catabolic process during apoptosis, DNA catabolism during apoptosis, DNA fragmentation involved in apoptotic nuclear change, endonucleolytic DNA catabolic process involved in apoptosis, DNA fragmentation, chromatinolysis
Alternate IDs: GO:0008178
Definition: The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments. Source: GOC:dph, GOC:tb, PMID:15723341, PMID:23379520, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976
Comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341).
History: See term history for GO:0006309 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to apoptotic DNA fragmentation (excluding "regulates").; Link to all direct and indirect annotations to apoptotic DNA fragmentation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for apoptotic DNA fragmentation (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0009987 cellular process
GO:0008219 cell death
GO:0008152 metabolic process
GO:0008150 biological_process
GO:0071840 cellular component organization or biogenesis
GO:0044238 primary metabolic process
GO:0012501 programmed cell death
GO:0006915 apoptotic process
GO:0009056 catabolic process
GO:0016043 cellular component organization
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0022411 cellular component disassembly
GO:0097194 execution phase of apoptosis
GO:0009057 macromolecule catabolic process
GO:0090304 nucleic acid metabolic process
GO:0034655 nucleobase-containing compound catabolic process
GO:0006921 cellular component disassembly involved in execution phase of apoptosis
GO:0006259 DNA metabolic process
GO:0141188 nucleic acid catabolic process
GO:0030262 apoptotic nuclear changes
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:1902511 negative regulation of apoptotic DNA fragmentation
GO:1902512 positive regulation of apoptotic DNA fragmentation
GO:1902510 regulation of apoptotic DNA fragmentation

Parents of apoptotic DNA fragmentation (GO:0006309)

subject	relation	object
apoptotic DNA fragmentation	RO:0002162	Opisthokonta (NCBITaxon:33154)
apoptotic DNA fragmentation	BFO:0000050	apoptotic nuclear changes (GO:0030262)
apoptotic DNA fragmentation	is_a	DNA catabolic process (GO:0006308)

Children of apoptotic DNA fragmentation (GO:0006309)

subject	relation	object
positive regulation of apoptotic DNA fragmentation (GO:1902512)	RO:0002213	apoptotic DNA fragmentation
negative regulation of apoptotic DNA fragmentation (GO:1902511)	RO:0002212	apoptotic DNA fragmentation
regulation of apoptotic DNA fragmentation (GO:1902510)	RO:0002211	apoptotic DNA fragmentation

Reactome: R-HSA-140342