AmiGO 2: Term Details for "apoptotic process" (GO:0006915)

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Term Information

Accession: GO:0006915
Name: apoptotic process
Ontology: biological_process
Synonyms: apoptotic cell death, apoptotic programmed cell death, programmed cell death by apoptosis, apoptosis activator activity, caspase-dependent programmed cell death, commitment to apoptosis, induction of apoptosis, induction of apoptosis by p53, signaling (initiator) caspase activity, activation of apoptosis, apoptosis, apoptosis signaling, apoptotic program, type I programmed cell death, cell suicide, cellular suicide
Alternate IDs: GO:0006917, GO:0008632
Definition: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. Source: GOC:tb, ISBN:0198506732, PMID:21494263, GOC:go_curators, GOC:mtg_apoptosis, GOC:cjm, GOC:ecd, PMID:18846107, GOC:dhl
Comment: None
History: See term history for GO:0006915 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to apoptotic process (excluding "regulates").; Link to all direct and indirect annotations to apoptotic process (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for apoptotic process (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0009987 cellular process
GO:0008219 cell death
GO:0012501 programmed cell death
GO:0006915 apoptotic process
GO:0043276 anoikis
GO:0008637 apoptotic mitochondrial changes
GO:0071839 apoptotic process in bone marrow cell
GO:0140208 apoptotic process in response to mitochondrial fragmentation
GO:1902742 apoptotic process involved in development
GO:0097190 apoptotic signaling pathway
GO:0072577 endothelial cell apoptotic process
GO:1904019 epithelial cell apoptotic process
GO:0097194 execution phase of apoptosis
GO:1904606 fat cell apoptotic process
GO:0044346 fibroblast apoptotic process
GO:0034349 glial cell apoptotic process
GO:1902489 hepatoblast apoptotic process
GO:0006925 inflammatory cell apoptotic process
GO:0071887 leukocyte apoptotic process
GO:1902362 melanocyte apoptotic process
GO:0097152 mesenchymal cell apoptotic process
GO:0010657 muscle cell apoptotic process
GO:0033028 myeloid cell apoptotic process
GO:1904516 myofibroblast cell apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0051402 neuron apoptotic process
GO:0016505 peptidase activator activity involved in apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0042981 regulation of apoptotic process
GO:1990009 retinal cell apoptotic process

Parents of apoptotic process (GO:0006915)

subject	relation	object
apoptotic process	is_a	programmed cell death (GO:0012501)
apoptotic process	RO:0002224	apoptotic signaling pathway (GO:0097190)
apoptotic process	RO:0002230	execution phase of apoptosis (GO:0097194)
apoptotic process	RO:0002162	Opisthokonta (NCBITaxon:33154)

Children of apoptotic process (GO:0006915)

subject	relation	object
epithelial cell apoptotic process (GO:1904019)	is_a	apoptotic process
retinal cell apoptotic process (GO:1990009)	is_a	apoptotic process
anoikis (GO:0043276)	is_a	apoptotic process
myofibroblast cell apoptotic process (GO:1904516)	is_a	apoptotic process
negative regulation of apoptotic process (GO:0043066)	RO:0002212	apoptotic process
melanocyte apoptotic process (GO:1902362)	is_a	apoptotic process
symbiont-mediated perturbation of host apoptosis (GO:0052150)	RO:0002010	apoptotic process
positive regulation of apoptotic process (GO:0043065)	RO:0002213	apoptotic process
endothelial cell apoptotic process (GO:0072577)	is_a	apoptotic process
apoptotic process involved in development (GO:1902742)	is_a	apoptotic process
symbiont-mediated activation of host apoptosis (GO:0052151)	RO:0012013	apoptotic process
apoptotic process in response to mitochondrial fragmentation (GO:0140208)	is_a	apoptotic process
fibroblast apoptotic process (GO:0044346)	is_a	apoptotic process
leukocyte apoptotic process (GO:0071887)	is_a	apoptotic process
regulation of apoptotic process (GO:0042981)	RO:0002211	apoptotic process
neuron apoptotic process (GO:0051402)	is_a	apoptotic process
glial cell apoptotic process (GO:0034349)	is_a	apoptotic process
symbiont-mediated suppression of host apoptosis (GO:0033668)	RO:0012014	apoptotic process
muscle cell apoptotic process (GO:0010657)	is_a	apoptotic process
mesenchymal cell apoptotic process (GO:0097152)	is_a	apoptotic process
peptidase activator activity involved in apoptotic process (GO:0016505)	BFO:0000050	apoptotic process
fat cell apoptotic process (GO:1904606)	is_a	apoptotic process
myeloid cell apoptotic process (GO:0033028)	is_a	apoptotic process
apoptotic process in bone marrow cell (GO:0071839)	is_a	apoptotic process
apoptotic mitochondrial changes (GO:0008637)	BFO:0000050	apoptotic process
apoptotic signaling pathway (GO:0097190)	BFO:0000050	apoptotic process
inflammatory cell apoptotic process (GO:0006925)	is_a	apoptotic process
hepatoblast apoptotic process (GO:1902489)	is_a	apoptotic process
execution phase of apoptosis (GO:0097194)	BFO:0000050	apoptotic process

Reactome: R-HSA-109581
Wikipedia: Apoptosis