AmiGO 2: Term Details for "epidermal growth factor catabolic process" (GO:0007174)

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Term Information

Accession: GO:0007174
Name: epidermal growth factor catabolic process
Ontology: biological_process
Synonyms: EGF breakdown, EGF catabolism, epidermal growth factor breakdown, epidermal growth factor catabolism, EGF receptor ligand processing, epidermal growth factor ligand processing, intracellular EGF processing, receptor-mediated EGF processing
Alternate IDs: None
Definition: The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor. Source: GOC:signaling, PMID:2985587, GOC:bf
Comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'.
History: See term history for GO:0007174 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to epidermal growth factor catabolic process (excluding "regulates").; Link to all direct and indirect annotations to epidermal growth factor catabolic process (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for epidermal growth factor catabolic process (excluding "regulates").

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GO:0008150 biological_process
GO:0065007 biological regulation
GO:0007165 signal transduction
GO:0007154 cell communication
GO:0007166 cell surface receptor signaling pathway
GO:0009987 cellular process
GO:0048519 negative regulation of biological process
GO:0050789 regulation of biological process
GO:0050794 regulation of cellular process
GO:0050896 response to stimulus
GO:0023052 signaling
GO:0051716 cellular response to stimulus
GO:0007167 enzyme-linked receptor protein signaling pathway
GO:0008152 metabolic process
GO:0048523 negative regulation of cellular process
GO:0010646 regulation of cell communication
GO:0048583 regulation of response to stimulus
GO:0023051 regulation of signaling
GO:0009056 catabolic process
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0038127 ERBB signaling pathway
GO:0010648 negative regulation of cell communication
GO:0048585 negative regulation of response to stimulus
GO:0023057 negative regulation of signaling
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0009966 regulation of signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0043170 macromolecule metabolic process
GO:0009968 negative regulation of signal transduction
GO:1901575 organic substance catabolic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:1901184 regulation of ERBB signaling pathway
GO:0009057 macromolecule catabolic process
GO:1901185 negative regulation of ERBB signaling pathway
GO:1901565 organonitrogen compound catabolic process
GO:0019538 protein metabolic process
GO:0042058 regulation of epidermal growth factor receptor signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0030163 protein catabolic process
GO:0007174 epidermal growth factor catabolic process

Parents of epidermal growth factor catabolic process (GO:0007174)

subject	relation	object
epidermal growth factor catabolic process	is_a	negative regulation of epidermal growth factor receptor signaling pathway (GO:0042059)
epidermal growth factor catabolic process	is_a	protein catabolic process (GO:0030163)

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