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peptide-methionine (S)-S-oxide reductase activity

Term Information

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Accession
GO:0008113
Name
peptide-methionine (S)-S-oxide reductase activity
Ontology
molecular_function
Synonyms
methionine sulfoxide (protein) reductase activity, peptide-methionine-(S)-S-oxide reductase activity, protein-methionine-S-oxide reductase activity, MsrA, methionine S-oxide reductase (S-form oxidizing) activity, methionine sulfoxide reductase A activity, methionine sulphoxide reductase A activity, peptide Met(O) reductase activity, peptide methionine sulfoxide reductase activity, peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity, methionine S-oxide reductase activity, methionine sulfoxide reductase activity
Alternate IDs
GO:0033742, GO:0072561
Definition
Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin. Source: GOC:vw, GOC:mah, PMID:11169920, EC:1.8.4.11
Comment
None
History
See term history for GO:0008113 at QuickGO
Chem. react.
has participant L-methionine residue
has participant L-cysteine residue
has participant water
has participant L-methionine (S)-S-oxide residue
has participant L-cystine residue
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of peptide-methionine (S)-S-oxide reductase activity (GO:0008113)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
peptide-methionine (S)-S-oxide reductase activity [RO:0000057 relation] RO:0000057  L-methionine residue (CHEBI:16044)
peptide-methionine (S)-S-oxide reductase activity [RO:0000057 relation] RO:0000057  L-cysteine residue (CHEBI:29950)
peptide-methionine (S)-S-oxide reductase activity [RO:0000057 relation] RO:0000057  water (CHEBI:15377)
peptide-methionine (S)-S-oxide reductase activity [is_a relation] is_a  oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor (GO:0016671)
peptide-methionine (S)-S-oxide reductase activity [RO:0000057 relation] RO:0000057  L-methionine (S)-S-oxide residue (CHEBI:44120)
peptide-methionine (S)-S-oxide reductase activity [RO:0000057 relation] RO:0000057  L-cystine residue (CHEBI:50058)

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