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cholesterol 7-alpha-monooxygenase activity

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Accession
GO:0008123
Name
cholesterol 7-alpha-monooxygenase activity
Ontology
molecular_function
Synonyms
cholesterol 7-alpha-hydroxylase activity, cholesterol 7alpha-hydroxylase activity, cholesterol 7alpha-monooxygenase activity, cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating), cytochrome P450 CYP7A1
Alternate IDs
None
Definition
Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O. Source: EC:1.14.14.23
Comment
None
History
See term history for GO:0008123 at QuickGO
Chem. react.
has participant cholesterol
has participant FMN(3-)
has participant FMNH2(2-)
has participant 7alpha-hydroxycholesterol
has participant dioxygen
has participant water
has participant hydron
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of cholesterol 7-alpha-monooxygenase activity (GO:0008123)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
cholesterol 7-alpha-monooxygenase activity [RO:0000057 relation] RO:0000057  cholesterol (CHEBI:16113)
cholesterol 7-alpha-monooxygenase activity [is_a relation] is_a  steroid hydroxylase activity (GO:0008395)
cholesterol 7-alpha-monooxygenase activity [RO:0000057 relation] RO:0000057  FMN(3-) (CHEBI:58210)
cholesterol 7-alpha-monooxygenase activity [RO:0000057 relation] RO:0000057  FMNH2(2-) (CHEBI:57618)
cholesterol 7-alpha-monooxygenase activity [RO:0000057 relation] RO:0000057  7alpha-hydroxycholesterol (CHEBI:17500)
cholesterol 7-alpha-monooxygenase activity [RO:0000057 relation] RO:0000057  dioxygen (CHEBI:15379)
cholesterol 7-alpha-monooxygenase activity [RO:0000057 relation] RO:0000057  water (CHEBI:15377)
cholesterol 7-alpha-monooxygenase activity [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)
cholesterol 7-alpha-monooxygenase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)

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