AmiGO 2: Term Details for "IkappaB kinase activity" (GO:0008384)

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Term Information

Accession: GO:0008384
Name: IkappaB kinase activity
Ontology: molecular_function
Synonyms: ATP:IkappaB protein phosphotransferase activity, CHUK, IKBKA, IKBKB, IKK, IKK-1, IKK-2, STK12, TBK1, inhibitor of NF-kappaB kinase activity, inhibitor of NFkappaB kinase activity, TANK-binding kinase 1 activity
Alternate IDs: None
Definition: Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein. Source: EC:2.7.11.10
Comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB.
History: See term history for GO:0008384 at QuickGO
Chem. react.: has participant L-serine residue; has participant ATP(4-); has participant ADP(3-); has participant hydron; has participant O-phospho-L-serine(2-) residue
Subset: None
Related: Link to all genes and gene products annotated to IkappaB kinase activity (excluding "regulates").; Link to all direct and indirect annotations to IkappaB kinase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for IkappaB kinase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
GO:0008150 biological_process
CARO:0000006 material anatomical entity
GO:0065007 biological regulation
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0009987 cellular process
GO:0005575 cellular_component
GO:0008152 metabolic process
GO:0050789 regulation of biological process
GO:0050896 response to stimulus
GO:0003824 catalytic activity
CL:0000000 cell
GO:0007154 cell communication
GO:0110165 cellular anatomical entity
GO:0044237 cellular metabolic process
GO:0051716 cellular response to stimulus
GO:0006807 nitrogen compound metabolic process
GO:0071704 organic substance metabolic process
GO:0050794 regulation of cellular process
GO:0023052 signaling
GO:0005622 intracellular anatomical structure
GO:0043170 macromolecule metabolic process
GO:0003674 molecular_function
GO:1901564 organonitrogen compound metabolic process
GO:0006793 phosphorus metabolic process
GO:0044238 primary metabolic process
GO:0007165 signal transduction
GO:0016740 transferase activity
GO:0035556 intracellular signal transduction
GO:0043412 macromolecule modification
GO:0006796 phosphate-containing compound metabolic process
GO:0019538 protein metabolic process
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0140096 catalytic activity, acting on a protein
GO:0141124 intracellular signaling cassette
GO:0016301 kinase activity
GO:0016310 phosphorylation
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0036211 protein modification process
GO:0007249 canonical NF-kappaB signal transduction
GO:0004672 protein kinase activity
GO:0006468 protein phosphorylation
GO:0007252 I-kappaB phosphorylation
GO:0004674 protein serine/threonine kinase activity
GO:0008384 IkappaB kinase activity
GO:0008385 IkappaB kinase complex

Parents of IkappaB kinase activity (GO:0008384)

subject	relation	object
IkappaB kinase activity	RO:0000057	L-serine residue (CHEBI:29999)
IkappaB kinase activity	is_a	protein serine/threonine kinase activity (GO:0004674)
IkappaB kinase activity	RO:0000057	ATP(4-) (CHEBI:30616)
IkappaB kinase activity	RO:0000057	ADP(3-) (CHEBI:456216)
IkappaB kinase activity	BFO:0000050	I-kappaB phosphorylation (GO:0007252)
IkappaB kinase activity	RO:0000057	hydron (CHEBI:15378)
IkappaB kinase activity	RO:0000057	O-phospho-L-serine(2-) residue (CHEBI:83421)

Children of IkappaB kinase activity (GO:0008384)

subject	relation	object
IkappaB kinase complex (GO:0008385)	RO:0002215	IkappaB kinase activity

EC: 2.7.11.10
MetaCyc: 2.7.11.10-RXN
Reactome: R-HSA-5684275; R-HSA-5684267
RHEA: 19073