Term Information

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Accession
GO:0008385
Name
IkappaB kinase complex
Ontology
cellular_component
Synonyms
IKK complex, heterotrimeric IKK complex, trimeric IKK complex
Alternate IDs
None
Definition
A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. Source: GOC:bf, GOC:ma, PMID:20300203, PMID:12055104
Comment
None
History
See term history for GO:0008385 at QuickGO
Chem. react.
None
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of IkappaB kinase complex (GO:0008385)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
IkappaB kinase complex [is_a relation] is_a  serine/threonine protein kinase complex (GO:1902554)
IkappaB kinase complex [BFO:0000050 relation] BFO:0000050  cytosol (GO:0005829)
IkappaB kinase complex [RO:0002215 relation] RO:0002215  IkappaB kinase activity (GO:0008384)
IkappaB kinase complex [RO:0002162 relation] RO:0002162  cellular organisms (NCBITaxon:131567)

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