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Accession
GO:0008398
Name
sterol 14-demethylase activity
Ontology
molecular_function
Synonyms
lanosterol 14alpha-demethylase activity, sterol 14-alpha-demethylase activity, sterol 14alpha-demethylase activity, cytochrome P450 51 activity, cytochrome P450 CYP51, lanosterol 14-alpha-demethylase activity, lanosterol 14-demethylase activity, obtusufoliol 14-demethylase activity
Alternate IDs
None
Definition
Catalysis of the reaction: a 14alpha-methyl steroid + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = a delta14 steroid + formate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase]. Source: RHEA:54028
Comment
None
History
See term history for GO:0008398 at QuickGO
Chem. react.
has participant water
has participant Delta(14) steroid
has participant hydron
has participant 14alpha-methyl steroid
has participant dioxygen
has participant formate
has participant FMN(3-)
has participant FMNH2(2-)
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Parents of sterol 14-demethylase activity (GO:0008398)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  water (CHEBI:15377)
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  Delta(14) steroid (CHEBI:138031)
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  14alpha-methyl steroid (CHEBI:138029)
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  dioxygen (CHEBI:15379)
sterol 14-demethylase activity [is_a relation] is_a  demethylase activity (GO:0032451)
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  formate (CHEBI:15740)
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  FMN(3-) (CHEBI:58210)
sterol 14-demethylase activity [RO:0000057 relation] RO:0000057  FMNH2(2-) (CHEBI:57618)
sterol 14-demethylase activity [is_a relation] is_a  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen (GO:0016709)

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