Term Information

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Accession
GO:0008425
Name
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
Ontology
molecular_function
Synonyms
2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity, coenzyme Q biosynthesis methyltransferase activity, coenzyme Q biosynthetic process methyltransferase activity, ubiquinone biosynthesis methyltransferase activity, ubiquinone biosynthetic process methyltransferase activity
Alternate IDs
None
Definition
Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine. Source: PMID:23190198, PMID:9083048, GOC:kd
Comment
Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
History
See term history for GO:0008425 at QuickGO
Chem. react.
has participant S-adenosyl-L-homocysteine zwitterion
has participant S-adenosyl-L-methionine zwitterion
has participant hydron
has participant 2-methoxy-6-all-trans-polyprenylhydroquinone
has participant 2-methoxy-3-methyl-6-all-trans-polyprenylhydroquinone
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0008425 from QuickGO

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Parents of 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity (GO:0008425)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [is_a relation] is_a  C-methyltransferase activity (GO:0008169)
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-methionine zwitterion (CHEBI:59789)
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [BFO:0000050 relation] BFO:0000050  ubiquinone biosynthetic process (GO:0006744)
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [RO:0000057 relation] RO:0000057  2-methoxy-6-all-trans-polyprenylhydroquinone (CHEBI:84166)
2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity [RO:0000057 relation] RO:0000057  2-methoxy-3-methyl-6-all-trans-polyprenylhydroquinone (CHEBI:84167)

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EC
2.1.1.201
Reactome
R-HSA-2162188
RHEA
28286