AmiGO 2: Term Details for "oxidized purine nucleobase lesion DNA N-glycosylase activity" (GO:0008534)

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Term Information

Accession: GO:0008534
Name: oxidized purine nucleobase lesion DNA N-glycosylase activity
Ontology: molecular_function
Synonyms: oxidized purine base lesion DNA N-glycosylase activity, 2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity, 2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity, DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing], DNA-formamidopyrimidine glycosylase activity, Fapy-DNA glycosylase activity, Fpg protein, deoxyribonucleate glycosidase activity, formamidopyrimidine-DNA glycosylase activity, purine-specific oxidized base lesion DNA N-glycosylase activity, 8-oxoguanine DNA glycosylase activity, DNA glycosylase/AP-lyase activity, DNA glycosylase/beta-lyase activity, bifunctional DNA glycosylase activity
Alternate IDs: GO:0003907
Definition: Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site. Source: PMID:11554296, GOC:elh
Comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'.
History: See term history for GO:0008534 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to oxidized purine nucleobase lesion DNA N-glycosylase activity (excluding "regulates").; Link to all direct and indirect annotations to oxidized purine nucleobase lesion DNA N-glycosylase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for oxidized purine nucleobase lesion DNA N-glycosylase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0003824 catalytic activity
GO:0003674 molecular_function
GO:0016787 hydrolase activity
GO:0140640 catalytic activity, acting on a nucleic acid
GO:0016798 hydrolase activity, acting on glycosyl bonds
GO:0140097 catalytic activity, acting on DNA
GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds
GO:0019104 DNA N-glycosylase activity
GO:0000702 oxidized base lesion DNA N-glycosylase activity
GO:0008534 oxidized purine nucleobase lesion DNA N-glycosylase activity
GO:0034039 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity

Parents of oxidized purine nucleobase lesion DNA N-glycosylase activity (GO:0008534)

subject	relation	object
oxidized purine nucleobase lesion DNA N-glycosylase activity	is_a	oxidized base lesion DNA N-glycosylase activity (GO:0000702)

Children of oxidized purine nucleobase lesion DNA N-glycosylase activity (GO:0008534)

subject	relation	object
8-oxo-7,8-dihydroguanine DNA N-glycosylase activity (GO:0034039)	is_a	oxidized purine nucleobase lesion DNA N-glycosylase activity

EC: 3.2.2.23
MetaCyc: 3.2.2.23-RXN
Reactome: R-HSA-110229; R-HSA-110243; R-HSA-110244