AmiGO 2: Term Details for "translational attenuation" (GO:0009386)

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Term Information

Accession: GO:0009386
Name: translational attenuation
Ontology: biological_process
Synonyms: None
Alternate IDs: None
Definition: Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation. Source: PMID:15805513, PMID:15694341
Comment: None
History: See term history for GO:0009386 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to translational attenuation (excluding "regulates").; Link to all direct and indirect annotations to translational attenuation (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for translational attenuation (excluding "regulates").

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GO:0009987 cellular process
GO:0050789 regulation of biological process
GO:0008150 biological_process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
GO:0065007 biological regulation
GO:0044249 cellular biosynthetic process
GO:0008152 metabolic process
GO:0009889 regulation of biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0009059 macromolecule biosynthetic process
GO:0071704 organic substance metabolic process
GO:0031326 regulation of cellular biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0010467 gene expression
GO:0043170 macromolecule metabolic process
GO:1901576 organic substance biosynthetic process
GO:1901564 organonitrogen compound metabolic process
GO:0044238 primary metabolic process
GO:0010556 regulation of macromolecule biosynthetic process
GO:1901566 organonitrogen compound biosynthetic process
GO:0019538 protein metabolic process
GO:0010468 regulation of gene expression
GO:0080090 regulation of primary metabolic process
GO:0010608 post-transcriptional regulation of gene expression
GO:0051246 regulation of protein metabolic process
GO:0006412 translation
GO:0006417 regulation of translation
GO:0009386 translational attenuation

Parents of translational attenuation (GO:0009386)

subject	relation	object
translational attenuation	is_a	regulation of translation (GO:0006417)

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