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fatty acid elongase activity

Term Information

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Accession
GO:0009922
Name
fatty acid elongase activity
Ontology
molecular_function
Synonyms
ELOVL, elongation of very long chain fatty acids activity, very-long-chain 3-ketoacyl-CoA synthase, very-long-chain 3-oxoacyl-CoA synthase, very-long-chain beta-ketoacyl-CoA synthase, condensing enzyme
Alternate IDs
None
Definition
Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit. Source: PMID:16564093, RHEA:32727, PMID:19763486
Comment
None
History
See term history for GO:0009922 at QuickGO
Chem. react.
has participant coenzyme A(4-)
has participant carbon dioxide
has participant very long-chain 3-oxoacyl-CoA(4-)
has participant very long-chain acyl-CoA(4-)
has participant malonyl-CoA(5-)
has participant hydron
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0009922 from QuickGO

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Parents of fatty acid elongase activity (GO:0009922)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
fatty acid elongase activity [RO:0000057 relation] RO:0000057  coenzyme A(4-) (CHEBI:57287)
fatty acid elongase activity [is_a relation] is_a  acyltransferase activity, transferring groups other than amino-acyl groups (GO:0016747)
fatty acid elongase activity [RO:0000057 relation] RO:0000057  carbon dioxide (CHEBI:16526)
fatty acid elongase activity [RO:0000057 relation] RO:0000057  very long-chain 3-oxoacyl-CoA(4-) (CHEBI:90725)
fatty acid elongase activity [RO:0000057 relation] RO:0000057  very long-chain acyl-CoA(4-) (CHEBI:90736)
fatty acid elongase activity [RO:0000057 relation] RO:0000057  malonyl-CoA(5-) (CHEBI:57384)
fatty acid elongase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
Children of fatty acid elongase activity (GO:0009922)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
fatty acid elongase complex (GO:0009923) [RO:0002215 relation] RO:0002215  fatty acid elongase activity