Term Information

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Accession
GO:0010420
Name
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
Ontology
molecular_function
Synonyms
polyprenyldihydroxybenzoate methyltransferase activity
Alternate IDs
GO:1990886
Definition
Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+. Source: PMID:23190198, PMID:9628017, RHEA:44452, PMID:10419476
Comment
Note that the polyprenyl sidechain substrate for this reaction has a different number of prenyl units in different organisms (for example, ubiquinone-6 in Saccharomyces, ubiquinone- 9 in rat and ubiquinone-10 in human), and thus the natural substrate for the enzymes from different organisms has a different number of prenyl units. However, the enzyme usually shows a low degree of specificity regarding the number of prenyl units.
History
See term history for GO:0010420 at QuickGO
Chem. react.
has participant hydron
has participant 3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate
has participant S-adenosyl-L-homocysteine zwitterion
has participant 3,4-dihydroxy-5-polyprenylbenzoate
has participant S-adenosyl-L-methionine zwitterion
Subset
None
Include "regulates"
For more information, please see the ontology relation documentation.

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Graph of GO:0010420 from QuickGO

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Parents of 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity (GO:0010420)
subject[Reorder by subject] relation[Reorder by relation] object[Reorder by object]
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [RO:0000057 relation] RO:0000057  hydron (CHEBI:15378)
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [RO:0000057 relation] RO:0000057  3-methoxy-4-hydroxy-5-all-trans-polyprenylbenzoate (CHEBI:84443)
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-homocysteine zwitterion (CHEBI:57856)
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [is_a relation] is_a  S-adenosylmethionine-dependent methyltransferase activity (GO:0008757)
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [BFO:0000050 relation] BFO:0000050  ubiquinone biosynthetic process (GO:0006744)
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [RO:0000057 relation] RO:0000057  3,4-dihydroxy-5-polyprenylbenzoate (CHEBI:64694)
3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity [RO:0000057 relation] RO:0000057  S-adenosyl-L-methionine zwitterion (CHEBI:59789)

This term has no children.

EC
2.1.1.114
MetaCyc
RXN-9281
Reactome
R-HSA-2162193
RHEA
44452