AmiGO 2: Term Details for "NADPH-adrenodoxin reductase activity" (GO:0015039)

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Term Information

Accession: GO:0015039
Name: NADPH-adrenodoxin reductase activity
Ontology: molecular_function
Synonyms: adrenodoxin-type ferredoxin reductase activity, NADPH:adrenodoxin oxidoreductase activity, adrenodoxin reductase activity
Alternate IDs: None
Definition: Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+. Source: RHEA:42312, GOC:kd
Comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'.
History: See term history for GO:0015039 at QuickGO
Chem. react.: has participant NADP(3-); has participant di-mu-sulfido-diiron(2+); has participant NADPH(4-); has participant hydron; has participant di-mu-sulfido-diiron(1+)
Subset: None
Related: Link to all genes and gene products annotated to NADPH-adrenodoxin reductase activity (excluding "regulates").; Link to all direct and indirect annotations to NADPH-adrenodoxin reductase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for NADPH-adrenodoxin reductase activity (excluding "regulates").

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GO:0003674 molecular_function
GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016730 oxidoreductase activity, acting on iron-sulfur proteins as donors
GO:0016731 oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
GO:0015039 NADPH-adrenodoxin reductase activity

Parents of NADPH-adrenodoxin reductase activity (GO:0015039)

subject	relation	object
NADPH-adrenodoxin reductase activity	RO:0000057	NADP(3-) (CHEBI:58349)
NADPH-adrenodoxin reductase activity	RO:0000057	di-mu-sulfido-diiron(2+) (CHEBI:33737)
NADPH-adrenodoxin reductase activity	RO:0000057	NADPH(4-) (CHEBI:57783)
NADPH-adrenodoxin reductase activity	RO:0000057	hydron (CHEBI:15378)
NADPH-adrenodoxin reductase activity	is_a	oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor (GO:0016731)
NADPH-adrenodoxin reductase activity	RO:0000057	di-mu-sulfido-diiron(1+) (CHEBI:33738)

This term has no children.

EC: 1.18.1.6
MetaCyc: RXN-13685
RHEA: 42312