AmiGO 2: Term Details for "polyketide synthase activity" (GO:0016218)

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Term Information

Accession: GO:0016218
Name: polyketide synthase activity
Ontology: molecular_function
Synonyms: PKS activity
Alternate IDs: None
Definition: Catalysis of a multistep reaction that produce polyketides through decarboxylative condensation of carboxylic acids. The key chain-building reaction, a C-N bond-forming reaction, involves the generation of the characteristic peptide bond by nucleophilic attack of the amino group of an amino-acyl donor unit covalently bound to a downstream peptidyl carrier protein module (amino acyl-S-PCP) on the acyl group of an upstream electrophilic acyl- or peptidyl acyl-S-PCP chain, catalyzed by a condensation (C) domain. Supplementing these core chain-elongation domains are variable numbers of auxiliary domains that are responsible for modification of the growing polypeptide chain by a small set of iterated reactions including epimerization, N-methylation, and heterocyclization. Source: PMID:10631508
Comment: None
History: See term history for GO:0016218 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to polyketide synthase activity (excluding "regulates").; Link to all direct and indirect annotations to polyketide synthase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for polyketide synthase activity (excluding "regulates").

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GO:0008150 biological_process
GO:0008152 metabolic process
GO:0009058 biosynthetic process
GO:0071704 organic substance metabolic process
GO:0019748 secondary metabolic process
GO:0003674 molecular_function
GO:1901576 organic substance biosynthetic process
GO:0030638 polyketide metabolic process
GO:0044550 secondary metabolite biosynthetic process
GO:0003824 catalytic activity
GO:0030639 polyketide biosynthetic process
GO:0016218 polyketide synthase activity

Parents of polyketide synthase activity (GO:0016218)

subject	relation	object
polyketide synthase activity	BFO:0000050	polyketide biosynthetic process (GO:0030639)
polyketide synthase activity	is_a	catalytic activity (GO:0003824)

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