AmiGO 2: Term Details for "RNA polymerase II general transcription initiation factor activity" (GO:0016251)

Notice

Some functionality on this page depends on JavaScript. To fully use the features of AmiGO 2, enable JavaScript in your browser and reload from the landing page.

Term Information

Accession: GO:0016251
Name: RNA polymerase II general transcription initiation factor activity
Ontology: molecular_function
Synonyms: GTF2 activity, basal RNA polymerase II transcription factor activity, general RNA polymerase II transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly, sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly, transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding, transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly
Alternate IDs: GO:0003703, GO:0000983, GO:0001075
Definition: A general transcription initiation factor activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP). In most species, RNA polymerase II transcribes all messenger RNAs (mRNAs), most untranslated regulatory RNAs, the majority of the snoRNAs, four of the five snRNAs (U1, U2, U4, and U5), and other small noncoding RNAs. For some small RNAs there is variability between species as to whether it is transcribed by RNA polymerase II or RNA polymerase III. However there are also rare exceptions, such as Trypanosoma brucei, where RNA polymerase I transcribes certain mRNAs in addition to its normal role in rRNA transcription. Source: PMID:25693126, GOC:txnOH-2018, PMID:10384286, PMID:23442138, PMID:10747032
Comment: General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur.
History: See term history for GO:0016251 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to RNA polymerase II general transcription initiation factor activity (excluding "regulates").; Link to all direct and indirect annotations to RNA polymerase II general transcription initiation factor activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for RNA polymerase II general transcription initiation factor activity (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

Filter results

View this term in QuickGO.

Additional external viewing options

OLSVis (interactive)

Additional internal viewing options

GO:0008150 biological_process
GO:0009987 cellular process
GO:0008152 metabolic process
GO:0071704 organic substance metabolic process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0044238 primary metabolic process
GO:0044249 cellular biosynthetic process
GO:0090304 nucleic acid metabolic process
GO:1901362 organic cyclic compound biosynthetic process
GO:0009059 macromolecule biosynthetic process
GO:0141187 nucleic acid biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0016070 RNA metabolic process
GO:0010467 gene expression
GO:0032774 RNA biosynthetic process
GO:0006351 DNA-templated transcription
GO:0003674 molecular_function
GO:0140223 general transcription initiation factor activity
GO:0006366 transcription by RNA polymerase II
GO:0016251 RNA polymerase II general transcription initiation factor activity

Parents of RNA polymerase II general transcription initiation factor activity (GO:0016251)

subject	relation	object
RNA polymerase II general transcription initiation factor activity	BFO:0000050	transcription by RNA polymerase II (GO:0006366)
RNA polymerase II general transcription initiation factor activity	is_a	general transcription initiation factor activity (GO:0140223)

This term has no children.