AmiGO 2: Term Details for "RISC complex" (GO:0016442)

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Term Information

Accession: GO:0016442
Name: RISC complex
Ontology: cellular_component
Synonyms: RNA-induced silencing complex, miRNP complex, micro-ribonucleoprotein complex
Alternate IDs: GO:0035068
Definition: A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation. Source: PMID:10749213, PMID:15145345
Comment: None
History: See term history for GO:0016442 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to RISC complex (excluding "regulates").; Link to all direct and indirect annotations to RISC complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for RISC complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0005575 cellular_component
PR:000050567 protein-containing material entity
GO:0032991 protein-containing complex
GO:1990904 ribonucleoprotein complex
GO:0031332 RNAi effector complex
GO:0016442 RISC complex

Parents of RISC complex (GO:0016442)

subject	relation	object
RISC complex	is_a	RNAi effector complex (GO:0031332)

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Wikipedia: RNA-induced_silencing_complex