AmiGO 2: Term Details for "mediator complex" (GO:0016592)

Term Information

Accession: GO:0016592
Name: mediator complex
Ontology: cellular_component
Synonyms: L mediator complex, Srb-mediator complex, CDK8-containing TRAP/mediator complex, TRAP complex
Alternate IDs: GO:0000119
Definition: A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins. Source: PMID:16168358, PMID:11454195, PMID:17870225
Comment: None
History: See term history for GO:0016592 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to mediator complex (excluding "regulates").; Link to all direct and indirect annotations to mediator complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for mediator complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
UBERON:0000061 anatomical structure
GO:0005575 cellular_component
CL:0000000 cell
GO:0110165 cellular anatomical structure
GO:0005622 intracellular anatomical structure
GO:0043226 organelle
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
GO:0043231 intracellular membrane-bounded organelle
GO:0005634 nucleus
GO:0032991 protein-containing complex
GO:0140513 nuclear protein-containing complex
GO:0016592 mediator complex

Parents of mediator complex (GO:0016592)

subject	relation	object
mediator complex	is_a	nuclear protein-containing complex (GO:0140513)
mediator complex	RO:0002162	Eukaryota (NCBITaxon:2759)
mediator complex	BFO:0000051	core mediator complex (GO:0070847)

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Wikipedia: Mediator_(coactivator)