AmiGO 2: Term Details for "phospholipid scramblase activity" (GO:0017128)

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Term Information

Accession: GO:0017128
Name: phospholipid scramblase activity
Ontology: molecular_function
Synonyms: None
Alternate IDs: None
Definition: Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism. Source: PMID:20302864, PMID:20043909, GOC:cjm
Comment: Nomenclature note. Scramblases are ATP-independent, non-selective, translocases inducing non-specific transbilayer movements across the membrane. Flippases and floppases are ATP-dependent transbilayer lipid translocators. According to an extensively used, though not universal, nomenclature, they catalyze lipid transfer towards the inward monolayer (flippases) or towards the outward monolayer (floppases).
History: See term history for GO:0017128 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to phospholipid scramblase activity (excluding "regulates").; Link to all direct and indirect annotations to phospholipid scramblase activity (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for phospholipid scramblase activity (excluding "regulates").

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For more information, please see the ontology relation documentation.

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GO:0008150 biological_process
GO:0051179 localization
GO:0009987 cellular process
GO:0051234 establishment of localization
GO:0065007 biological regulation
GO:0071840 cellular component organization or biogenesis
GO:0033036 macromolecule localization
GO:0006810 transport
GO:0016043 cellular component organization
GO:0010876 lipid localization
GO:0061024 membrane organization
GO:0003674 molecular_function
GO:0071702 organic substance transport
GO:0065008 regulation of biological quality
GO:0010256 endomembrane system organization
GO:0034204 lipid translocation
GO:0006869 lipid transport
GO:0015748 organophosphate ester transport
GO:0015914 phospholipid transport
GO:0097035 regulation of membrane lipid distribution
GO:0005215 transporter activity
GO:0005319 lipid transporter activity
GO:0045332 phospholipid translocation
GO:0007009 plasma membrane organization
GO:0140303 intramembrane lipid transporter activity
GO:0005548 phospholipid transporter activity
GO:0017121 plasma membrane phospholipid scrambling
GO:0017128 phospholipid scramblase activity
GO:1900162 negative regulation of phospholipid scramblase activity
GO:1900163 positive regulation of phospholipid scramblase activity
GO:1900161 regulation of phospholipid scramblase activity

Parents of phospholipid scramblase activity (GO:0017128)

subject	relation	object
phospholipid scramblase activity	is_a	phospholipid transporter activity (GO:0005548)
phospholipid scramblase activity	is_a	intramembrane lipid transporter activity (GO:0140303)
phospholipid scramblase activity	BFO:0000050	plasma membrane phospholipid scrambling (GO:0017121)

Children of phospholipid scramblase activity (GO:0017128)

subject	relation	object
positive regulation of phospholipid scramblase activity (GO:1900163)	RO:0002213	phospholipid scramblase activity
negative regulation of phospholipid scramblase activity (GO:1900162)	RO:0002212	phospholipid scramblase activity
phosphatidylserine exposure on apoptotic cell surface (GO:0070782)	BFO:0000051	phospholipid scramblase activity
regulation of phospholipid scramblase activity (GO:1900161)	RO:0002211	phospholipid scramblase activity

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