AmiGO 2: Term Details for "cyclin-dependent protein kinase activating kinase holoenzyme complex" (GO:0019907)

Term Information

Accession: GO:0019907
Name: cyclin-dependent protein kinase activating kinase holoenzyme complex
Ontology: cellular_component
Synonyms: CAK complex, CDK-activating kinase complex
Alternate IDs: None
Definition: A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH. Source: PMID:8752210, GOC:bhm
Comment: None
History: See term history for GO:0019907 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to cyclin-dependent protein kinase activating kinase holoenzyme complex (excluding "regulates").; Link to all direct and indirect annotations to cyclin-dependent protein kinase activating kinase holoenzyme complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for cyclin-dependent protein kinase activating kinase holoenzyme complex (excluding "regulates").

Include "regulates"
For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
CARO:0000000 anatomical entity
UBERON:0001062 anatomical entity
CARO:0000006 material anatomical entity
GO:0008150 biological_process
GO:0009058 biosynthetic process
GO:0044237 cellular metabolic process
GO:0009987 cellular process
CARO:0000003 connected anatomical structure
UBERON:0000465 material anatomical entity
GO:0008152 metabolic process
GO:0006807 nitrogen compound metabolic process
GO:0048518 positive regulation of biological process
GO:0044238 primary metabolic process
GO:0050789 regulation of biological process
GO:0050794 regulation of cellular process
GO:0019222 regulation of metabolic process
UBERON:0000061 anatomical structure
GO:0044249 cellular biosynthetic process
GO:0005575 cellular_component
GO:0043170 macromolecule metabolic process
GO:0006139 nucleobase-containing compound metabolic process
GO:0048522 positive regulation of cellular process
GO:0009893 positive regulation of metabolic process
GO:0009889 regulation of biosynthetic process
GO:0031323 regulation of cellular metabolic process
GO:0051171 regulation of nitrogen compound metabolic process
GO:0080090 regulation of primary metabolic process
GO:0065007 biological regulation
GO:0003824 catalytic activity
CL:0000000 cell
GO:0110165 cellular anatomical entity
GO:0009059 macromolecule biosynthetic process
GO:0071704 organic substance metabolic process
GO:0009891 positive regulation of biosynthetic process
GO:0031325 positive regulation of cellular metabolic process
GO:0051173 positive regulation of nitrogen compound metabolic process
GO:0032991 protein-containing complex
GO:0031326 regulation of cellular biosynthetic process
GO:0060255 regulation of macromolecule metabolic process
GO:0019219 regulation of nucleobase-containing compound metabolic process
GO:0016070 RNA metabolic process
GO:0005488 binding
GO:1902494 catalytic complex
GO:0007049 cell cycle
GO:0006725 cellular aromatic compound metabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0010467 gene expression
GO:0046483 heterocycle metabolic process
GO:1901363 heterocyclic compound binding
GO:0005622 intracellular anatomical structure
GO:0003674 molecular_function
GO:1901265 nucleoside phosphate binding
GO:0043226 organelle
GO:1901360 organic cyclic compound metabolic process
GO:1901576 organic substance biosynthetic process
GO:0031328 positive regulation of cellular biosynthetic process
GO:0010604 positive regulation of macromolecule metabolic process
GO:0045935 positive regulation of nucleobase-containing compound metabolic process
GO:0010556 regulation of macromolecule biosynthetic process
GO:0051252 regulation of RNA metabolic process
GO:0032774 RNA biosynthetic process
GO:0016740 transferase activity
GO:0019438 aromatic compound biosynthetic process
GO:0097367 carbohydrate derivative binding
GO:0022402 cell cycle process
GO:0006351 DNA-templated transcription
GO:0018130 heterocycle biosynthetic process
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
GO:0000278 mitotic cell cycle
GO:0090304 nucleic acid metabolic process
GO:0000166 nucleotide binding
GO:1901362 organic cyclic compound biosynthetic process
GO:0010557 positive regulation of macromolecule biosynthetic process
GO:0051254 positive regulation of RNA metabolic process
GO:0051726 regulation of cell cycle
GO:0010468 regulation of gene expression
GO:2001141 regulation of RNA biosynthetic process
GO:0036094 small molecule binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:1990234 transferase complex
GO:0140096 catalytic activity, acting on a protein
GO:0044770 cell cycle phase transition
GO:0006352 DNA-templated transcription initiation
GO:0008047 enzyme activator activity
GO:0043231 intracellular membrane-bounded organelle
GO:0043167 ion binding
GO:0019207 kinase regulator activity
GO:1903047 mitotic cell cycle process
GO:0098772 molecular function regulator activity
GO:0141187 nucleic acid biosynthetic process
GO:0034654 nucleobase-containing compound biosynthetic process
GO:0097159 organic cyclic compound binding
GO:1902680 positive regulation of RNA biosynthetic process
GO:0004672 protein kinase activity
GO:0017076 purine nucleotide binding
GO:0010564 regulation of cell cycle process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
GO:0032553 ribonucleotide binding
GO:0006366 transcription by RNA polymerase II
GO:0061695 transferase complex, transferring phosphorus-containing groups
GO:0030554 adenyl nucleotide binding
GO:0043168 anion binding
GO:0044843 cell cycle G1/S phase transition
GO:0044839 cell cycle G2/M phase transition
GO:0097472 cyclin-dependent protein kinase activity
GO:0030234 enzyme regulator activity
GO:0019209 kinase activator activity
GO:0016301 kinase activity
GO:0044772 mitotic cell cycle phase transition
GO:0140677 molecular function activator activity
GO:0005634 nucleus
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0045893 positive regulation of DNA-templated transcription
GO:1902911 protein kinase complex
GO:0019887 protein kinase regulator activity
GO:0004674 protein serine/threonine kinase activity
PR:000050567 protein-containing material entity
GO:0032555 purine ribonucleotide binding
GO:1901987 regulation of cell cycle phase transition
GO:2000142 regulation of DNA-templated transcription initiation
GO:0007346 regulation of mitotic cell cycle
GO:0140994 RNA polymerase II CTD heptapeptide repeat modifying activity
GO:1902554 serine/threonine protein kinase complex
GO:0006367 transcription initiation at RNA polymerase II promoter
GO:0032559 adenyl ribonucleotide binding
GO:0000307 cyclin-dependent protein kinase holoenzyme complex
GO:0006354 DNA-templated transcription elongation
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0140513 nuclear protein-containing complex
GO:2000144 positive regulation of DNA-templated transcription initiation
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0030295 protein kinase activator activity
GO:0035639 purine ribonucleoside triphosphate binding
GO:1902806 regulation of cell cycle G1/S phase transition
GO:1902749 regulation of cell cycle G2/M phase transition
GO:1901990 regulation of mitotic cell cycle phase transition
GO:0060260 regulation of transcription initiation by RNA polymerase II
GO:0008353 RNA polymerase II CTD heptapeptide repeat kinase activity
GO:0005524 ATP binding
GO:0032806 carboxy-terminal domain protein kinase complex
GO:0019912 cyclin-dependent protein kinase activating kinase activity
GO:0150005 enzyme activator complex
GO:0019908 nuclear cyclin-dependent protein kinase holoenzyme complex
GO:0060261 positive regulation of transcription initiation by RNA polymerase II
GO:2000045 regulation of G1/S transition of mitotic cell cycle
GO:0010389 regulation of G2/M transition of mitotic cell cycle
GO:0006368 transcription elongation by RNA polymerase II
GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex

Parents of cyclin-dependent protein kinase activating kinase holoenzyme complex (GO:0019907)

subject	relation	object
cyclin-dependent protein kinase activating kinase holoenzyme complex	RO:0002216	positive regulation of transcription initiation by RNA polymerase II (GO:0060261)
cyclin-dependent protein kinase activating kinase holoenzyme complex	RO:0002216	transcription elongation by RNA polymerase II (GO:0006368)
cyclin-dependent protein kinase activating kinase holoenzyme complex	RO:0002216	protein kinase regulator activity (GO:0019887)
cyclin-dependent protein kinase activating kinase holoenzyme complex	is_a	nuclear cyclin-dependent protein kinase holoenzyme complex (GO:0019908)
cyclin-dependent protein kinase activating kinase holoenzyme complex	RO:0002216	regulation of G1/S transition of mitotic cell cycle (GO:2000045)
cyclin-dependent protein kinase activating kinase holoenzyme complex	is_a	carboxy-terminal domain protein kinase complex (GO:0032806)
cyclin-dependent protein kinase activating kinase holoenzyme complex	is_a	enzyme activator complex (GO:0150005)
cyclin-dependent protein kinase activating kinase holoenzyme complex	RO:0002215	cyclin-dependent protein kinase activating kinase activity (GO:0019912)
cyclin-dependent protein kinase activating kinase holoenzyme complex	RO:0002215	ATP binding (GO:0005524)
cyclin-dependent protein kinase activating kinase holoenzyme complex	RO:0002216	regulation of G2/M transition of mitotic cell cycle (GO:0010389)

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