AmiGO 2: Term Details for "AP-2 adaptor complex" (GO:0030122)

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Term Information

Accession: GO:0030122
Name: AP-2 adaptor complex
Ontology: cellular_component
Synonyms: HA2, HA2 clathrin adaptor
Alternate IDs: None
Definition: A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC). Source: PMID:22022230, PMID:10611976, GOC:mah, PMID:21097499, PMID:24322426
Comment: None
History: See term history for GO:0030122 at QuickGO
Chem. react.: None
Subset: None
Related: Link to all genes and gene products annotated to AP-2 adaptor complex (excluding "regulates").; Link to all direct and indirect annotations to AP-2 adaptor complex (excluding "regulates").; Link to all direct and indirect annotations download (limited to first 10,000) for AP-2 adaptor complex (excluding "regulates").

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For more information, please see the ontology relation documentation.

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CARO:0030000 biological entity
GO:0005622 intracellular anatomical structure
GO:0043226 organelle
CARO:0000000 anatomical entity
GO:0110165 cellular anatomical structure
GO:0043229 intracellular organelle
GO:0043227 membrane-bounded organelle
UBERON:0001062 anatomical entity
GO:0043231 intracellular membrane-bounded organelle
CARO:0000006 material anatomical entity
GO:0031982 vesicle
CL:0000000 cell
CARO:0000003 connected anatomical structure
GO:0005737 cytoplasm
GO:0031410 cytoplasmic vesicle
GO:0097708 intracellular vesicle
UBERON:0000465 material anatomical entity
GO:0016020 membrane
GO:0031090 organelle membrane
UBERON:0000061 anatomical structure
GO:0098588 bounding membrane of organelle
GO:0005575 cellular_component
GO:0030135 coated vesicle
GO:0030659 cytoplasmic vesicle membrane
GO:0012506 vesicle membrane
GO:0030136 clathrin-coated vesicle
GO:0048475 coated membrane
GO:0030662 coated vesicle membrane
GO:0030139 endocytic vesicle
GO:0030117 membrane coat
GO:0098796 membrane protein complex
GO:0071944 cell periphery
GO:0030118 clathrin coat
GO:0045334 clathrin-coated endocytic vesicle
GO:0030665 clathrin-coated vesicle membrane
GO:0030666 endocytic vesicle membrane
GO:0012505 endomembrane system
GO:0032991 protein-containing complex
GO:0030120 vesicle coat
GO:0030119 AP-type membrane coat adaptor complex
GO:0030125 clathrin vesicle coat
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0005905 clathrin-coated pit
GO:0005886 plasma membrane
GO:0098797 plasma membrane protein complex
GO:0030131 clathrin adaptor complex
GO:0030132 clathrin coat of coated pit
GO:0030128 clathrin coat of endocytic vesicle
GO:0030122 AP-2 adaptor complex

Parents of AP-2 adaptor complex (GO:0030122)

subject	relation	object
AP-2 adaptor complex	RO:0002162	cellular organisms (NCBITaxon:131567)
AP-2 adaptor complex	BFO:0000050	clathrin coat of endocytic vesicle (GO:0030128)
AP-2 adaptor complex	is_a	plasma membrane protein complex (GO:0098797)
AP-2 adaptor complex	is_a	clathrin adaptor complex (GO:0030131)
AP-2 adaptor complex	BFO:0000050	clathrin coat of coated pit (GO:0030132)

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